Modification of the Arachidonic Acid Cascade by Long-Chain W-3 Fatty Acids

  • Peter C. Weber


Physiological and pathophysiological reactions like vascular resistance, thrombosis, wound healing, inflammation and allergy are modulated by oxygenated metabolites of arachidonic acid (AA; 20:4w−6 or 20:4n−6) and related polyunsaturated fatty acids that are collectively termed eicosanoids. These compounds include prostaglandins, prostacyclin, thromboxane, leukotrienes and other oxygenated derivatives of arachidonic acid. The eicosanoids are all derived from essential fatty acids that must be provided in the diet, and production of eicosanoids is controlled by cellular mechanisms for the uptake, release and oxygenation of the eicosanoid precursor fatty acids.


Platelet Activate Factor Arachidonic Acid Cascade Eicosanoid Formation Thromboxane Formation Eicosanoid Precursor 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Peter C. Weber
    • 1
  1. 1.Institut fur die Prophylaxe der Kreislaufkrankheitenb.d. Universitat MunchenMunchen 2Germany

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