Abstract
The tissue uptake and metabolism of the various ω3 and ω6 fatty acids are influenced by a number of factors. Of great importance is the fat content and the fatty acid composition of the diet. Both linoleic and α-linolenic acid are metabolised by the same enzyme system and the affinity for the enzyme system depends upon the degree of unsaturation and chain-length. This means that the ratio of linoleic to α-linolenic acid in the diet, rather than the absolute amount, strongly influences their conversion and incorporation into lipids (Alling et al., 1972, 1974; Becker, 1985). Taking these factors into account, the problems in making relevant comparisons of essential fatty acid (EFA) metabolism within and between species are obvious.
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Adam, O., Wolfram, G., and Zöllner, N., Wirkung der Linol–and Linolensäure auf die Prostaglandinbildung and die Nierfunktion beam Menschen. Fette Seifen-Anstrichmittel., 1984, 86, 180–183.
Ailing, C., Bruce, A., Karlsson, I., Sapia, 0., and Svennerholm, L., 1972, Effect of maternal essential fatty acid supply on fatty acid composition of brain, liver, muscle and serum in 21-day-old rats. J Nutr. 102, 773–782.
Alling, C., Bruce, A., Karlsson, I., and Svennerholm, L., 1974, The effect of different dietary levels of essential fatty acids on lipids of rat cerebrum during matuation. J. Neurochem. 23, 1263–1270.
Ailing, C., Bruce, A., Karlsson, I., and Svennerholm, L., 1976, The effect of different dietary levels of essential fatty acids on liver and serum lipids in rat. Nutr. Metabol. 20, 440–451.
Ailing, C., Becker, W., Jones A. W., and Anggârd, E., 1984, Effects of chronic ethanol treatment on lipid composition and prostaglandins in rats fed essential fatty acid deficient diets. Alcholism: Clin. Exp. Res. 8, 238–242.
Becker, W., 1984, Distribution of i4C after oral administration of 1–14Clinoleic acid in rats fed different levels of essential fatty acids. J. Nutr., 114, 1690–1696.
Becker, W., 1985, Thesis, Acta Univ. Ups. Abstracts of Uppsala Dissertations from the Faculty of Medicine. 513, Uppsala.
Becker, W., and Bruce, A., Retention of linoleic acid in carcass lipids of rats fed different levels of essential fatty acids. Manuscript.
Becker, W., Bruce, A., and L rsson, B., 1983, Autoradiographic studies with albumin-bound 1–1 C-linoleic acid in normal and essential fatty acid-deficient rats. A pilot study. Ann. Nutr. Metab., 27, 415–424.
Becker, W., and Mânsson J. E., 1985, Incorporation of 14C into tissue lipids after oral administration of 1–1 C-linoleic acid in rats fed different levels of essential fatty acids. J. Nutr., 115, 1248–1258.
Becker, W., and Bruce, A, 1985, Autoradiographic studies with fatty acids and some other lipids: a review. Prog. Lipid Res., 24, 325–346.
Becker, W., Mohammed, A., And Slanina, P., 1985, Uptake of radiolabelled a-linolenic, arachidonic and oleic acid in tissues of normal and essential fatty acid deficient rats - an autoradidographic study. Ann. Nutr. Metab., 29, 65–75.
Becker, W., and Nilsson A., 1988, Unpublished.
Blass, K-E., P., Mentz, P., and Förster, W., 1978, Effects of unsaturated fatty acids on canine coronary flow. Acta Biol. Med. Germ., 37, 765–767.
Boberg, M., Vessby, B., and Selenius, I., 1986, Effects of dietary supplementation with n-6 and n-3 long-chain polyunsaturated fatty acids on serum lipoproteins and platelet function in hypertriglyceridaemic patients. Acta Med. Scand., 220, 153–160.
Bruce, A., 1974a, Changes in the concentration and fatty acid composition of phospholipids in rat skeletal muscle during postnatal development. Acta Physiol. Scand., 90, 743–749.
Bruce, A., 1974b, Skeletal muscle lipids. III. Changes in fatty acid composition of individual phosphoglycerides in man from fetal to middle age. J. Lip. Res., 15, 109–113.
Bruckner, G. G., German, B., Lokesh, B., and Kinsella, J. E., 1984, Biosynthesis of prostanoids, tissue fatty acid composition and thrombotic parameters in rats fed diets enriched with docosahexaenoic (22:6n3) or eicosapentaenoic (20:5n3) acids. Thrombosis Res., 34, 479–497.
Charnock, J. S., McLennan, P. L., Abeywardena, M. Y., and Russel, G. R., 1985a, Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. Ann. Nutr. Metab. 29: 279–288.
Charnock, J. S., McLennan, P. L., Abeywardena, M. Y., and Dryden, W. F., 1985b, Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. Ann. Nutr. Metab., 29, 306–318.
Charnock, J. S., Abeywardena, M. Y., and McLennan, P. L., 1986, Comparative changes in the fatty-acid composition of rat cardiac phospholipids after long-term feeding of sunflower seed oil-or tuna fish oil supplemented diets. Ann. Nutr. Metab. 30, 393–406.
Croft, K. D., Beilin, L. J., Legge, F. M., and Vandongen, R., 1987, Effects of diets enriched in eicosapentaenoic or docosahexaenoic acids on prostanoid metabolism in the rat. Lipids, Vol 22, 647–650.
Cunnane, S. C., Keeling, P. W. N., Thompson, R. P. H., and Crawford, M. A., 1984, Linoleic acid and arachidonic acid metabolism in human peri-feral blood lymphocytes: comparison with the rat. Br. J. Nutr., 51, 209–217.
Dyerberg, J., Bang, H. 0., and Hjorne, N., 1975, Fatty acid composition of the plasma lipids in Greenland Eskimos. Am. J. Clin. Nutr., 28, 958–966.
Dyerberg, J., and Bang, H. 0., 1979, Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet., ii, 433–435.
Field, J. C., and Clandinin, M. T., 1984, Modulation of adipose tissue fat composition by diet: a review. Nutr. Res., 4, 743–755.
Gudbjarnason, S., Doell, B., and Oskarsdottir, G., 1978, Docosahexaenoic acid in cardiac metabolism and function. Acta. Biol. Med. Germ., 37, 777–784.
Hamazaki, T., Urakaze, M., Makuta, M., Ozawa, A., Soda, Y., Tatsumi, H., Yano, S., and Kumagai, A., 1987, Intake of different eicosapentaenoic acid-containing lipids and fatty acid pattern of plasma lipids in the rats. Lipids., 22, 994–998.
Heckers, H., Körner, M., Tuschen, T. W. L., and Melcher, F. W., 1977, Occurence of individual trans-isomeric fatty acids in human myocardium, jejunum, and aorta in relation to different degrees of atherosclerosis. Atherosclerosis, 28, 389–398.
Holman, R. T., Smythe, L., and Johnson, S., 1979, Effect of sex and age on fatty acid composition on human serum lipids. Am. J. Clin. Nutr., 32, 2390–2399.
Holmer, G., and Beare-Rogers, J. L., 1985, Linseed oil and marine oil as sources of (N-3) fatty acids in rat heart. Nutr. Res., 5, 1011–1014.
Horrobin, D. F., Huang, Y-S., Cunnane, S. C., and Manku, M. S., 1984, Essential fatty acids in plasma, red blood cells and liver phospholipids in common laboratory animals as compared to humans. Lipids 19, 806–811.
Jackson, M. J., Roberts, J., and Edwards, R. H. T., 1988, Dietary fish oil supplementation modifies rat skeletal muscle fatty acid composition but does not influence the response of muscles to experimental damage. Proc. Nutr. Soc., 47, 32A.
Kinsella, J. E., 1987, “Seafoods and fish oils in human health and disease”, Marcel Dekker, inc., New York and Basel.
Leyton, J., Drury, P. J., and Crawford, M. A., 1987, Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat. Br. J. Nutr., 57:383–393.
Martinez, M., and Ballabriga, A., 1987, Effects of parenteral nutrition with high doses of linoleate on the developing liver and brain. Lipids, 22, 133–138.
Needleman, P., 1976, The synthesis and functions of prostaglandins in the heart. Fed. Proc., 35, 2376–2381.
Nichaman, M. Z., Olsonf4R. E. and Sweeley, C. C., 1967, Metabolism of linoleic acid-1- C in normolipemic and hyperlipemic humans fed linoleate diets. Am. J. Clin. Nutr., 20, 1070–1083.
Ormsby, J. W., Schnatz, J. D4 and Williams, R. H., 1963, The incorporation of linoleic-1- C acid in human plasma and adipose tissue. Metabolism, 12, 812–820.
Poovaiah, B. P., Tinoco J., and Lyman, R. L., 1976, Influence of diet on conversion of 1–14C-linolenic acid to docosahexaenoic acid in the rat. Lipids, 11, 194–202.
Roshanai, F., and Sanders, T. A. B., 1985, Influence of different supplements of n-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. Ann. Nutr. Metab., 29, 189–196.
Sanders, T. A. B., and Younger, K. M., 1981, The effect of dietary supplements of w3 polyunsaturated fatty acids on the fatty acid composition of platelets and plasma choline phosphoglycerides. Br. J. Nutr., 45, 613–616.
Sanders, T. A. B., 1985, The importance of eicosapentaenoic and docosahexaenoic acids. In: “The Role of Fats in Human Nutrition” (eds P. B. Padley, J. Podmore, J.P. Brun, R. Burt, B.W. Nicols ) pp. 101–116, Ellis Horwood, Chichester.
von Schacky, C. and Weber, P.C., 1985, Metabolism and effects on platelet. function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J. Clin. Invest., 76, 2446–2450.
Schlenk, H., Sand, D. M., and Gellerman, J. L., 1969, Retroconversion of docosahexaenoic acid in the rat. Biochim. Biophys. Acta, 187, 201–207.
Sinclair, A.J., 1975, Incorporation of radioactive polyunsaturated fatty acids into liver and brain of developing rat. Lipids 10, 175–184.
Singer, P., Wirth, M., and Berger, I., 1986, Zur mangelnden Synthese von Arachidon-und Eicosapentaensäure aus Linol-und a-Linolensäure in klinischen Experimenten. Akt. Ernähr., 11, 203–207.
Stone, K.J., Willis, A.L., Kirtland, S.J., Kernoff, P. B. A., and McNicol, G. P., 1979, The metabolism of dihomo-y-linolenic acid in man. Lipids, 14, 174–180.
Vanier, M-T., 1974, Contribution a l’étude des lipides cérébraux an cours du développement chez le foetus et le jenne enfant. Thesis. Lyon.
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Becker, W. (1989). Comparative Uptake in Rats and Man of ω3 and ω6 Fatty Acids. In: Galli, C., Simopoulos, A.P. (eds) Dietary ω3 and ω6 Fatty Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2043-3_11
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DOI: https://doi.org/10.1007/978-1-4757-2043-3_11
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