Lipid Peroxidation as a Possible Cause of Ochratoxin a Toxicity
Ochratoxin A (OA), a dihydroisocoumarin containing mycotoxin, is a widespread natural contaminant of a variety of food and feedstuffs at levels ranging from 9–27500 ug/kg (1). Ingestion of OA has been shown to induce nephropathy in several species (1) while dietary feeding induced renal adenomas and hepatocellular carcinomas in mice (2). OA did not produce genetic or related effects in a variety of in vitro, short termtests, but it has been shown to induce single strand breaks in DNA of liver, kidney and spleen (3). OA is suspected of being the main aetiologic agent responsible for Balkan endemic nephropathy (BEN) and associated urinary tract tumours, diseases which affect multiple members of families residing in restricted areas of Bulgaria, Yugoslavia and Romania (1).
KeywordsLipid Peroxidation Extensive Metabolizers Balkan Endemic Nephropathy Microsomal Lipid Peroxidation IARC Scientific Publication
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