Nephrotoxic Responses to Multiple Chemical Exposure
Contemporaneous exposure to more than one chemical represents a practical toxicological problem. The scientific community has long examined the effects of various single toxic agents on renal function in well-controlled laboratory experiments. These studies have given us insights into tubular sites of action of specific chemicals, mechanisms of actions (at least in some instances) and an understanding of the breadth of chemical substances which can produce damage to the kidney. Taken together, these investigations have been extremely valuable in describing, and provided part of the basis for an understanding of the chemically-induced nephrotoxic response resulting in acute renal failure. Perhaps most noteworthy are studies on the heavy metals, but a variety of organic compounds have also been studied almost as thoroughly. None of these studies, however, no matter how carefully conceived and conducted help the toxicologist address the “real world” problem. In fact, human exposure to toxic chemicals rarely occurs with a single substance, but rather to multiple substances. This is true with environmental exposures as well as those encountered in the industrial setting.
KeywordsMercuric Chloride Potassium Dichromate Sodium Selenate Basolateral Membrane Vesicle Renal Cortical Slice
Unable to display preview. Download preview PDF.
- Carmichael, N.G. and Fowler, B.A., 1980, Effects of separate and combined chronic mercuric chloride and sodium selenate administration in rats: histological, ultrastructural, and X-ray microanalytical studies of liver and kidney, J. Envir. Path. Toxicol., 3:399.Google Scholar
- Dial, W.G., Jr. and Evan, A.P., 1974, The effects of sodium chromate on the proximal tubules of the rat kidney, Lab. Invest., 6:704.Google Scholar
- Ganote, C.E., Reimer, K.A. and Jennings, R.B., 1974, Acute mercuric chloride nephrotoxicity, Lab. Invest., 6:633.Google Scholar
- Gritzka, T.L. and Trump, B.F., 1968, Renal tubular lesions caused by mercuric chloride, Am. J. Pathol., 6:1225.Google Scholar
- Jensen, R. and Berndt, W.O., 1987, Mercuric and chromate effects on renal vesicle membrane transport, Toxicologist, 7:28.Google Scholar