Induction of Hyaline Droplet Accumulation in Renal Cortex of Male Rats by Aromatic Compounds
Repeated oral and inhalation exposure of male rats to unleaded gasoline and a variety of petroleum-derived naphthas, solvents, and distillates has been reported to induce a characteristic spectrum of changes in the kidney which has been referred to as “light hydrocarbon nephropathy” (Mehlmann et al., 1984; Craig, 1986). Most of the identified compounds belong to the class of branched-chain alkanes. A select few of the investigated aromatics were inactive (Haider et al., 1984; Halder et al., 1985). Recently, corresponding effects were seen in short- and long-term studies with p-dichlorobenzene (NTP, 1986; Bomhard et al., 1987). Accumulation of hyaline droplets in the tubular epithelium occurs within a few days after treatment with these compounds and precedes the subsequent tubular lesions (Thomas et al., 1985). This study evaluated “light hydrocarbon nephropathy” inducing potential of several aromatic hydrocarbons by histological judgement of hyaline droplet accumulation (HDA).
KeywordsHydrocarbon Gasoline Naphtha Toxicology Chlorobenzene
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- Bomhard, E., Luckhaus, G. Voigt, W.-H. and Loeser, E. Induction of Light Hydrocarbons Nephropathy by p-Dichlorobenzene. Arch Toxicol., in press.Google Scholar
- Craig, P. Paper presented at the Toxicology Forum, 1986. Annual Summer Meeting, Aspen, Colorado.Google Scholar
- Fruehbeis, H., Klein, R. and Wallmeier, H. Computergestuetztes Molekueldesign (CAMD) — ein Ueberblick, Anaew. Chem., 99 (1987) 413–428.Google Scholar
- Halder, C.A., Holdsworth, C.E. and Cookrell, B.Y. Hydrocarbon Nephropathy in Male Rats. Identification of the Nephrotoxic Components of Gasoline. In: Monographs in Applied Toxicology. No. 2. Renal Heterogeneity and Target Cell Toxicity. P.H. Bach and E.A. Lock (eds.). John Wiley & Sons, Chichester, (1985) pp. 481–484.Google Scholar
- Halder, CA., Warne, T.M. and Hatoum, N.S. Renal Toxicity of Gasoline and Related Petroleum Naphthas in Male Rats. In.: Advances in Modern Environmental Toxicology. Vol. VII. Renal Effects of Petroleum Hydrocarbons. M.A. Mehlmann et al., (eds.) Princeton Scientific Publishers, Inc., Princeton, NY (1984) pp. 73–87.Google Scholar
- Mehlmann, M.A., Hemstreet, C.P., Thorpe, J.J. and Weaver, N.K. (eds.) Renal Effects of Petroleum Hydrocarbons. Advances In.: Modern Environmental Toxicology, Vol. VII., Princeton Scientific Publishers, Inc., Princeton, NY (1984).Google Scholar
- Ntp Technical Report on the Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CAS No. 106–46–7) in F 344/N Rats and B6c3f1 Mice (Gavage Studies). NIH Publication No. 86–2575, Department of Health and Human Services, Research Triangle Park, NC, 1986.Google Scholar
- Ntp Technical Report on the Carcinogenesis Bioassay of Pentachloroethane (CAS No. 76–01–7) in F 344/N Rats and B6c3f1 Mice (Gavage Studies) NIH Publication No., 83–1788, Department of Health and Human Services, Research Triangle Park, NC, 1983.Google Scholar
- Thomas, F.B., Halder, C.A., Holdsworth, CE. and Cockrell, B.Y. Hydrocarbon Nephropathy in Male Rats. Temporal and Morphological Characterization of the Renal Lesions. In.: Monographs in Applied Toxicology. Renal Heterogeneity and Target Cell Toxicity. P.H. Bach and E.A. Lock (eds.). John Wiley & Sons, Chichester, (1985).Google Scholar