Nephrotoxicity pp 503-507 | Cite as

31Phosphorus NMR Studies of Mercuric Chloride Nephrotoxicity in the in Vitro Perfused Rat Kidney

  • Z. H. Endre
  • P. J. Ratcliffe
  • L. G. Nicholls
  • J. G. G. Ledingham
  • J. D. Tange
  • G. K. Radda

Abstract

31P Nuclear Magnetic Resonance (NMR) studies of the effect of hypoxia on ATP levels in the isolated perfused rat kidney have shown that a step-wise decrease in oxygen delivery is associated with a step-wise decrease in ATP to a new plateau level (1). The decrement in ATP was closely correlated with the volume extent of cellular necrosis determined from morphometric analysis of the same kidneys at the end of the perfusion period.

Keywords

Mercuric Chloride Methylene Diphosphonate Fractional Sodium Excretion Hyperoncotic Albumin Krebs Bicarbonate Buffer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Z. H. Endre
    • 1
  • P. J. Ratcliffe
    • 1
  • L. G. Nicholls
    • 1
  • J. G. G. Ledingham
    • 1
  • J. D. Tange
    • 1
  • G. K. Radda
    • 1
  1. 1.Nuffield Department of clinical Medicine and Department of BiochemistryUniversity of OxfordOxfordUK

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