Nephrotoxicity pp 497-502 | Cite as

Renal Proton Nuclear Magnetic Resonance in Gentamicin, Cyclosporin a and Cisplatinum Acute Renal Failure in Rats

  • A. Iaina
  • S. Abrashkin
  • J. Weininger
  • R. Azoury

Abstract

Several studies suggest that it is possible to evaluate renal pathology by magnetic resonance imaging due to the sensitivity of the method in differentiating normal from pathological renal tissue (1–9). Proton magnetic resonance measurements are based on the properties of hydrogen nuclei that have spin. When placed in a magnetic field they orient themselves in the direction of the field. By application of a radio frequency pulse of suitable frequency, the direction of the spinning axis may be modified. After the pulse, the protons return to their original orientation emitting measurable signals. These signals grow and decay according to characteristic relaxation times; T1 “spin-lattice” (longitudinal) and T2 “spin-spin” (transverse) relaxation times. T1 reflects the interaction of the hydrogen nucleus with its molecular environment, whereas T2 reflects magnetic interactions between protons (10–12). In vitro magnetic resonance spectroscopy offers a direct measurement of different normal and abnormal tissues magnetic resonance properties (10–17). Using in vitro proton magnetic resonance measurements we demonstrated different profiles of relaxation times in different forms of experimental acute and chronic renal failure in rats (14,15).

Keywords

Acute Renal Failure Hydration Water Proton Nuclear Magnetic Resonance Proton Magnetic Resonance Measurement Radio Frequency Pulse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    R.E. Steiner, The Hammersmith clinical experience with nuclear magnetic resonance, Clinical Radiology. 34:13 (1983).PubMedCrossRefGoogle Scholar
  2. 2.
    H. Hricak, L. Crooks, P. Sheldon and L. Kaufman, Nuclear magnetic resonance imaging of the kidney, Radiology. 146:425 (1983).PubMedGoogle Scholar
  3. 3.
    H. Hricak and J.F. Newhouse, Magnetic resonance imaging of the kidney, Radiol. Clin. North Am. 22:287 (1984).PubMedGoogle Scholar
  4. 4.
    F.W. Smith, A. Reid, J.R. Mallard, J.M.S. Hutchinson, D.A. Pover, and G.R.D. Cato, Nuclear magnetic resonance tomographic imaging in renal disease, Diagnostic Imaging, 51:209 (1982).PubMedGoogle Scholar
  5. 5.
    L.J. Schultze, L. Te Strake, L.C. Paul, A.M. Tegzess, J.L. Bloem, J. Doornbos and R.G. Bluemm, Magnetic resonance imaging in renal transplants, In: “Proceedings EDTA-ERA” A.M. Davison and P.J. Guillou eds. Bailliere Tindal, London, pp 609–613 (1985).Google Scholar
  6. 6.
    I.R. Young, D.R. Bailes, M. Burl, A.G. Collins, D.T. Smith, M.J. MacDonald, J.S. Orr, L.M. Banks, G.M. Bydder, R.M. Greenspan and R.E. Steiner, Initial clinical evaluation of a whole body nuclear magnetic resonance (NMR) tomograph, J. Comput. Assist. Tomog. 6:1 (1982).CrossRefGoogle Scholar
  7. 7.
    F. Terrier, H. Hricak, D. Revel, C. Alpers, P. Bretan and N.J. Feduska, Magnetic resonance imaging in the diagnosis of acute allograft rejection and its differentiation from acute tubular necrosis necrosis; experimental study in the dog, Invest. Radiol. 20:617 (1985).PubMedCrossRefGoogle Scholar
  8. 8.
    H. Hricak, F. Terrier and B. Demas, Renal allografts: evaluation by MR imaging, Radiology. 159:435 (1986).PubMedGoogle Scholar
  9. 9.
    H. Hricak, F. Terrier, M. Marotti, B.L. Engelstad, R.A. Filly, F. Vincenti, R.M. Duca, P.N. Bretan, C.B. Higgins and N. Feduska, Posttransplant renal rejection: comparison of quantitative scintigraphy, US and MR imaging, Radiology., 162:685 (1987).PubMedGoogle Scholar
  10. 10.
    P.T. Beall, D. Medina and C.F. Hazelwood, The “systemic effect” of elevated tissue and serum relaxation times for water in animals and humans with cancer, In: “NMR medicine”, R. Damadian R, ed., Springer Verlag, New York, pp 39–57 (1981).CrossRefGoogle Scholar
  11. 11.
    I.L. Cameron, V.A. Ord and G.D. Fullerton, Characterization of proton NMR relaxation times in normal and pathological tissues by correlation with other tissue parameters, Magnetic Resonance Imaging, 2:97 (1984).PubMedCrossRefGoogle Scholar
  12. 12.
    G.D. Fullerton, J.L. Potter and N.C. Dornbluth, NMR relaxation of protons in tissues and other macromolecular water solutions, Magnetic Resonance Imaging, 1:209 (1982).PubMedCrossRefGoogle Scholar
  13. 13.
    Z.H. Endre and P.W. Küchel PW, Proton NMR spectroscopy of rabbit renal cortex, Kidney Int. 28:6 (1985).PubMedCrossRefGoogle Scholar
  14. 14.
    A. Iaina, S. Abrashkin and J. Weininger, Proton MR study of different types of experimental acute renal failure in rats, Magnetic Resonance Imaging, 4:241 (1986).PubMedCrossRefGoogle Scholar
  15. 15.
    S. Abrashkin, J. Weininger, L. Griffel, R. Schneider and A. Iaina, Proton magnetic resonance in experimental acute and chronic renal failure in rats, Renal Failure. 10:21 (1987).PubMedCrossRefGoogle Scholar
  16. 16.
    D. London, P. Davis, R. Williams, L. Crooks, P. Sheldon P and C. Gooding, Nuclear magnetic resonance imaging of induced renal lesions, Radiology. 148;167 (1983).PubMedGoogle Scholar
  17. 17.
    Y. Yuasa and H.L. Kundel, Magnetic resonance imaging following unilateral occlusion of the renal circulation in rabbits, Radiology. 154:151 (1985).PubMedGoogle Scholar
  18. 18.
    G.N. Ling, Hydration of macromolecules, In: “Water and aqueous solutions: Structure, thermodynamics and transport processes”, R. Home, ed., pp 663–670, Wiley Interscience, New York (1972).Google Scholar
  19. 19.
    R.K. Outhred and E.P. George, A nuclear magnetic resonance study of hydrated systems using the frequency dependence of the relaxation process, Biophys. J. 13:83 (1973).PubMedCrossRefGoogle Scholar
  20. 20.
    W.R. Inch, J.A. McCredie, C. Geiger and Y. Boctor, Spin-lattice relaxation times for mixtures of water and gelatin or cotton, compared with normal and malignant tissue, J. Nat. Cane. Inst. 53:689 (1974).Google Scholar
  21. 21.
    W.R. Inch, J.A. McCredie, R.R. Knispel, R.I. Thompson and M.M. Pintar, Water content and proton spin relaxation time for neoplastic and nonneoplastic tissues from mice and humans, J. Nat. Cane. Inst. 52:353 (1974).Google Scholar
  22. 22.
    H.J.C. Berendsen, Specific interactions of water with biopolymers, In: “Water a comprehensive treatise, Vol 5, Water in disperse systems”, F. Franks, ed. Plenum Press, New York, pp 293–330 (1975).Google Scholar
  23. 23.
    CF. Hazelwood, A view of the significance and understanding of the physical properties of cell-associated water, In: “Cell Associated Water”, J. Clegg and W. Drost-Hanson, eds. Academic Press, New York, pp 165–259 (1979).Google Scholar
  24. 24.
    R. Mathur-De Vre, The NMR studies of water in biological systems, Prog. Biophys. Biol. 35:103 (1979).CrossRefGoogle Scholar
  25. 25.
    K.R. Porter and J.B. Tucker, The ground substance of the living cell, Sci. Am. 244:56 (1981).PubMedCrossRefGoogle Scholar
  26. 26.
    A. Iaina, D. Herzog, D. Cohen, S. Gavendo, S. Kapuler, I. Serban, G. Schiby and H.E. Eliahou, Calcium entry blockade with verapamil in cyclosporine A plus ischemia induced acute renal failure in rats, Clinical Nephrol. 25 (suppl 1):168 (1986).Google Scholar
  27. 27.
    B.D. Kaha, Cyclosporine nephrotoxicity: pathogenesis, prophylaxis, therapy and prognosis, Am. J. Kidney. Dis. 8:323 (1986).Google Scholar
  28. 28.
    J.M. Weinberg, The role of calcium overload in nephrotoxic renal tubular cell injury, Am. J. Kidney Dis. 8:284 (1986).PubMedGoogle Scholar
  29. 29.
    R. Safirstein, J. Winston, M. Goldstein, P. Moel, S. Pickman and J. Guttenplan, Cisplatin nephrotoxicity, Am. J. Kidney Dis. 8:356 (1986).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • A. Iaina
    • 1
  • S. Abrashkin
    • 2
  • J. Weininger
    • 2
  • R. Azoury
    • 2
  1. 1.Department of NephrologyBarzilai Medical CentreAshqelonIsrael
  2. 2.Soreq Nuclear Research CentreYavneIsrael

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