Nephrotoxicity pp 491-496 | Cite as

Renal Effects of Ionic and Nonionic Contrast Media: Comparison between Diatrizoate Meglumine and Iopamidol

  • Carlo Donadio
  • Gianfranco Tramonti
  • Roberto Giordani
  • Amalia Lucchetti
  • Andrea Calderazzi
  • Paola Sbragia
  • Claudio Bianchi


Renal damage is a potential adverse side effect of the administration of iodinated contrast media (CM). Infact, CM represent one of the most frequent causes of renal failure (1,2). The renal damage determined by CM is sometimes irreversible (3). The mechanisms of this renal injury are not yet well understood. Hyperosmolality of the administered CM has been claimed to be an important factor of renal damage (4). No exhaustive data are available concerning the effects on renal function and nephrotoxicity of the different CM available. The aim of this study is the comparative evaluation of renal effects and nephrotoxicity of two different CM: diatrizoate meglumine (a high-osmolality ionic CM) and iopamidol (a new low-osmolality nonionic agent), after intravenous administration.


Toxicity Arthritis Filtration Urea Creatinine 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Carlo Donadio
    • 1
  • Gianfranco Tramonti
    • 1
  • Roberto Giordani
    • 1
  • Amalia Lucchetti
    • 1
  • Andrea Calderazzi
    • 1
  • Paola Sbragia
    • 1
  • Claudio Bianchi
    • 1
  1. 1.Clinica Medica 2, Istituto di RadiologiaUniversity of PisaPisaItaly

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