Nephrotoxicity pp 491-496 | Cite as

Renal Effects of Ionic and Nonionic Contrast Media: Comparison between Diatrizoate Meglumine and Iopamidol

  • Carlo Donadio
  • Gianfranco Tramonti
  • Roberto Giordani
  • Amalia Lucchetti
  • Andrea Calderazzi
  • Paola Sbragia
  • Claudio Bianchi

Abstract

Renal damage is a potential adverse side effect of the administration of iodinated contrast media (CM). Infact, CM represent one of the most frequent causes of renal failure (1,2). The renal damage determined by CM is sometimes irreversible (3). The mechanisms of this renal injury are not yet well understood. Hyperosmolality of the administered CM has been claimed to be an important factor of renal damage (4). No exhaustive data are available concerning the effects on renal function and nephrotoxicity of the different CM available. The aim of this study is the comparative evaluation of renal effects and nephrotoxicity of two different CM: diatrizoate meglumine (a high-osmolality ionic CM) and iopamidol (a new low-osmolality nonionic agent), after intravenous administration.

Keywords

Glomerular Filtration Rate Renal Damage Chronic Renal Insufficiency Renal Effect Intravenous Urography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    S.H. Hou, D.A. Bushinsky, I.B. Wish, J.J. Cohen, and J.T. Harrington, Hospital-acquired renal insufficiency: a prospective study, Am. J. Med. 74:243 (1983).PubMedCrossRefGoogle Scholar
  2. 2.
    D. Kleinknecht, P. Landais, and B. Goldfarb, Les insuffisances renales aigues associees h des medicaments ou A des produits de contraste iodes. Resultats d’une enquete cooperative multicentrique de la Societe de nephrologie, Nephrologie 7:41 (1986).PubMedGoogle Scholar
  3. 3.
    B.E. VanZee, W.E. Hoy, T.E. Talley, and J.R. Jaenike, Renal injury associated with intravenous pyelography in nondiabetic and diabetic patients, Am. Intern. Med. 89:51 (1978).CrossRefGoogle Scholar
  4. 4.
    J.B. Forrest, S.S. Howards, and I.Y. Gillenwater, Osmotic effects of intravenous contrast agents on renal function, J. Urol. 125:147 (1981).PubMedGoogle Scholar
  5. 5.
    C. Bianchi, Noninvasive methods for the measurement of renal function, In: “Renal function tests. Clinical laboratory procedures and diagnosis”, C.G. Duarte, ed., p. 65, Little, Brown, Boston (1980).Google Scholar
  6. 6.
    C. Bianchi, C. Donadio, and G. Tramonti, Noninvasive methods for the measurement of total renal function, Nephron 28:53 (1981).PubMedCrossRefGoogle Scholar
  7. 7.
    J.E. Peters, I. Schneider, and R.J. Haschen, Bestimmung der 1-Alanyl: Peptidhydrolase (Alanil-Aminopeptidase, Aminosaure-Arylamidase) immenschlichen Harn, Clin. Chim. Acta 36:289 (1972).CrossRefGoogle Scholar
  8. 8.
    G. Szasz, Gamma-Glutamyltranspeptidase-Aktivitat im Urin, Z. Klin. Chem. Klin. Biochem. 8:1 (1970).PubMedGoogle Scholar
  9. 9.
    L.J. Merle, M.M. Reindenberg, M.T. Camacho, B.R. Jones, and D.E. Drayer, Renal injury in patients with rheumatoid arthritis treated with gold, Clin. Pharmacol. Ther. 28:216 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    N. Milman, and P. Gottlieb, Renal function after high-dose urography in patients with chronic renal insufficiency, Clin. Nephrol. 7:250 (1977).PubMedGoogle Scholar
  11. 11.
    T. Shafi, S.Y. Chou, J.G. Porush, and W.B. Shapiro, Infusion intravenous pyelography and renal function. Effects in patients with chronic renal insufficiency, Arch. Intern. Med. 138:1218 (1978).PubMedCrossRefGoogle Scholar
  12. 12.
    A. Rahimi, R.P.S. Edmondson, and N.F. Jones, Effect of radiocontrast media on kidney of patients with renal disease, Br. Med. J. 282:1194 (1981).CrossRefGoogle Scholar
  13. 13.
    J.L. Teruel, R. Mareen, J.M. Onaindia, A. Serreno, C. Quereda, and J. Ortuno, Renal function impairment caused by intravenous urography, Arch. Intern. Med. 141:1271 (1981).PubMedCrossRefGoogle Scholar
  14. 14.
    G.A. Khoury, J.C. Hopper, Z. Varghese, K. Farrington, R. Dick, J.D. Irving, P. Sweny, O.N. Fernando, and J.F. Moorhead, Nephrotoxicity of ionic and non-ionic contrast material in digital vascular imaging and selective renal arteriography, Br. J. Radiol. 56:631 (1983).PubMedCrossRefGoogle Scholar
  15. 15.
    M.E. Gale, A.H. Robbins, R.J. Hamburger, and W.C. Widrich, Renal toxicity of contrast agents: iopamidol, iothalamate, and diatrizoate, Am. J. Roentgenol. 142:333 (1984).CrossRefGoogle Scholar
  16. 16.
    J.E. Scherberich, W. Mondorf, F.W. Falkenberg, D. Pierard, and W. Schoeppe, Monitoring drug nephrotoxicity. Quantitative estimation of human kidney brush border antigens in urine as a specific marker of tubular damage, Contrib. Nephrol. 42:81 (1984).PubMedGoogle Scholar
  17. 17.
    W.M. Thompson, W.L.Jr. Foster, R.A. Halvorsen, N.R. Dunnick, A.L. Rommel, and M. Bates, Iopamidol: new, nonionic contrast agent for excretory urography, Am. J. Roentgenol. 142:329 (1984).CrossRefGoogle Scholar
  18. 18.
    H.J. Smith, K. Levorstad, K.J. Berg, K. Rootwelt, and K. Sveen, High dose urography in patients with renal failure. A double blind investigation of iohexol and metrizoate, Acta Radiol. Diagn. 26:213 (1985).Google Scholar
  19. 19.
    G. Cavaliere, G. Arrigo, G. D’Amico, P. Bernasconi, G. Schiavina, L. Dellafiore, and D. Vergnaghi, Tubular nephrotoxicity after intravenous urography with ionic high-osmolal and nonionic low-osmolal contrast media in patients with chronic renal insufficiency, Nephron 46:128 (1987).PubMedCrossRefGoogle Scholar
  20. 20.
    R.F. Spataro, R.W. Katzberg, H.W. Fisher, and M.J. McMannis, High-dose clinical urography with the low-osmolality contrast agent hexabrix: comparison with a conventional contrast agent, Radiology 162:9 (1987).PubMedGoogle Scholar
  21. 21.
    C. Donadio, G. Tramonti, P. Lorusso, R. Giordani, A. Lucchetti, A. Calderazzi, C. Sbragia, P.L. Michelassi, and C. Bianchi, Effetti renali dei mezzi di contrasto: confronto tra diatrizoato di megluminae iopamidolo (risultati preliminari), G. Ital. Nefrol. in press.Google Scholar
  22. 22.
    S. Cedgard, H. Herlitz, K. Geterud, P. Attman, and M. Aurell, Acute renal insufficiency after administration of low-osmolar contrast media, Lancet 2:1281 (1986).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Carlo Donadio
    • 1
  • Gianfranco Tramonti
    • 1
  • Roberto Giordani
    • 1
  • Amalia Lucchetti
    • 1
  • Andrea Calderazzi
    • 1
  • Paola Sbragia
    • 1
  • Claudio Bianchi
    • 1
  1. 1.Clinica Medica 2, Istituto di RadiologiaUniversity of PisaPisaItaly

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