Nephrotoxicity pp 463-468 | Cite as

Studies on the Mechanism of Radiological Contrast Media Induced Renal Failure

  • C. J. Powell
  • M. Dobrota
  • E. Holtz

Abstract

Radiological contrast media are usually derivatives of tri-iodobenzoic acid that are used to render soft tissues x-ray opaque for diagnostic imaging. The procedure routinely employed for x-ray imaging the urinary tract (urography) consists of intravenous administration of a contrast medium, which is then rapidly concentrated in the kidney and excreted in the urine. It is generally assumed that these compounds do not enter cells, but remain within the extracellular space and are filtered at the glomeruli, concentrated within the tubular lumen and then excreted. For this reason contrast media have been described as dyes rather than drugs and are considered to be metabolically and physiologically inert.

Keywords

Contrast Medium Proximal Tubule Proximal Straight Tubule Renal Functional Reserve Light Microscopic Autoradiography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • C. J. Powell
    • 1
  • M. Dobrota
    • 2
  • E. Holtz
    • 3
  1. 1.DHSS Toxicology DepartmentSt Bartholomew’s Hospital Medical CollegeLondonUK
  2. 2.The Robens InstituteSurrey University GuildfordSurreyUK
  3. 3.Nycomed ASTorshov, OsloNorway

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