Nephrotoxicity pp 447-450 | Cite as

Nephrotoxicity of Ifosfamide in Combination Chemotherapy

  • Erhard Kurschel
  • Ulrike Metz-Kurschel


Ifosfamide (Ifos) is a structural analogue of cyclophosphamide with a broad spectrum of antineoplastic activities both in solid tumours and haematological neoplasia. Its most important side effects are haemorrhagic cystitis, haematotoxicity, neurotoxicity and nephrotoxicity (1–4). Haemorrhagic cystitis and to some extent nephrotoxicity can be ameliorated by concomitant administration of 2-mercaptoethane sulphonate sodium (Mesna R).


Toxicity Oncol Methotrexate Alanine Cyclophosphamide 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Erhard Kurschel
    • 1
  • Ulrike Metz-Kurschel
    • 2
  1. 1.West German Tumour CentreUniversity Medical SchoolEssenGermany
  2. 2.Department of Renal and Hypertensive DiseasesUniversity Medical SchoolEssenGermany

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