Nephrotoxicity pp 439-445 | Cite as

Celiptium Induced Lipid Peroxidation and Toxicity in Rat Renal Cortex

  • G. Raguenez-Viotte
  • C. Dadoun
  • A. M. Van den Bossche
  • J. P. Fillastre


The antitumour drug Celiptium (N2-methyl-9-hydroxyellipticinium) is an ellipticine derivative, effective in experimental tumours (1) and in man. Celiptium is metabolized in liver and excreted by the biliary tract (60%) and urine (30%). However, a renal metabolism occurs in both rats and humans treated with Celiptium, cysteine and N-acetylcysteine conjugates appear in the urine (2). Moreover, it was shown that isolated rat kidney cells metabolize Celiptium into the same conjugates which were found in rat or human urines whereas these compounds were not detected in bile (3).


Cholesterol Toxicity Glycerol Boron Iodine 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G. Raguenez-Viotte
    • 1
  • C. Dadoun
    • 1
  • A. M. Van den Bossche
    • 1
  • J. P. Fillastre
    • 1
  1. 1.INSERM U-295Universite de RouenSaint Etienne du RouvrayFrance

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