Nephrotoxicity pp 433-438 | Cite as

Effects of Antidotes on the Hepato- and Nephrotoxicity of Paracetamol in the Rat

  • Walter Moller-Hartmann
  • Claus-Peter Siegers


During intoxications with paracetamol hepatic and renal failure may develop, the latter also in the absence of liver damage (Boyer et al., 1971; Prescott et al., 1971; Cobden et al., 1982). Several antidotes are available for the treatment of severe paracetamol poisoning, these include mainly precursors of GSH-synthesis like methionine or N-acetylcysteine (Crome et al,. 1976; Prescott et al., 1977). In animal experiments diethyldithiocarbamate (dithiocarb) was shown to be an effective antidote against paracetamol-induced hepatotoxicity, due to its strong inhibitory influence on microsomal monooxygenases (Strubelt et al., 1974; Siegers et al., 1982). No experimental or clinical data, however, are available proving the efficacy of these antidotes in preventing paracetamol-induced renal damage. Moreover, it is still unclear, whether the metabolic pathways leading to hepatotoxic intermediates of paracetamol are the same for exerting nephrotoxic response.


Urea Glutathione Prostaglandin Methionine Indomethacin 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Walter Moller-Hartmann
    • 1
  • Claus-Peter Siegers
    • 1
  1. 1.Department of ToxicologyMedical University of LubeckLubeckGermany

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