Some Considerations on Critical Concentration of Cadmium for Renal Toxicity in Rats

  • Chiharu Tohyama
  • Naoko Sugihira
  • Kazuo T. Suzuki
  • Masataka Murakami
  • Hiroshi Saito


Cadmium (Cd) is a widespread toxic environmental pollutant. Environmental and occupational exposure results in the accumulation of this metal particularly in the liver and kidney and during the life-long exposure a renal Cd concentration becomes higher than a hepatic Cd concentration, which often causes renal tubular dysfunction (Friberg et al., 1985). Thus, we need to know the critical concentration of Cd to obtain information on the safety margin of exposure to this metal and the allowable daily intake levels.


Zinc Toxicity Chromate Lactate Cadmium 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Chiharu Tohyama
    • 1
  • Naoko Sugihira
    • 1
  • Kazuo T. Suzuki
    • 1
  • Masataka Murakami
    • 1
  • Hiroshi Saito
    • 1
  1. 1.Environmental Health Sciences DivisionNational Institute for Environmental StudiesOnogawa, Yatabe-machi, Tsukuba, Ibaraki 305Japan

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