Abstract
For many drugs the major route of elimination from the body is renal excretion. Therefore, a loss of renal function will lead to excessive accumulation of the drug or its metabolites in the body, unless the drug dosage is reduced. The problem is particularly acute for drugs that have a narrow therapeutic index intended for patients with severe renal insufficiency. A failure to appropriately adjust dosage can lead to toxicity, which for some drugs may be life-threatening.
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References
Fabre, J. and Balant, L. Renal failure, drug pharmacokinetics and drug action.Clin. Pharmacol., 1:99–120 (1976).
Dettli, L. Drug dosage in renal disease.Clin. Pharmacol., 1:126–134 (1976).
Burton, M.W., Vasko, M.R. and Brattier, D.C. Comparison of drug dosing methods.Clin. Pharmacol., 10:1–37 (1985).
Welling, P.G., Craig, W.A. and Kunin, M.C. Prediction of drug dosage in patients with renal failure using data derived from normal subjects.Clin. Pharmacol. Therap., 18:45–52 (1975).
Bricker, N.S., Morrin, P.A.F. and Kime, S.W. The pathologic physiology of chronic Bright‚ s disease.Am. J. Med., 28:77–98 (1960).
Bricker, N.S. Klahr, S., Lubowitz, H. and Rieselbach, R.E. Renal function in chronic renal disease.Medicine 44:263–288 (1965).
Cottier, P. and Haldemann, G. De l‚emploi d‚un Sulfamide (Ro — 4393) a duree d‚action prolongee dans le traitement de la pyelonephrite chronique.J. d‚Urol. Nephrol., 70:797–809 (1964).
Williams, O.M., Wimpenny, J. and Asscher, A.W. Renal clearance of sodium sulphadimidine in normal and uraemic subjects.Lancet 2:1058–1060 (1968).
Petipierre, B., Perrin, L., Rudhardt, M., Herrera, A. and Fabre, J. Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy.Int. J. Clin. Pharmacol., 6:120 (1972).
Shim, C. K., Sawada, Y., Iga, T. and Hanano, M. Estimation of renal secretory function for organic cations by endogenous N-methylnicotinamide in rats with experimental renal failure.J. Pharmaco. Biopharm., 12:23–42 (1984).
Giacomini, K.M., Roberts, S.M. and Levy, G. Evaluation of methods for producing renal dysfunction in rats.J. Pharm. Sci., 70:117–121 (1981)
Daley-Yates, P.T. and McBrien, D.C.H. Cisplatin nephrotoxicity. In: Nephrotoxicity, Assessment and Pathogenesis (eds. P.H. Bach, F.W. Bonner, J.W. Bridges and E.A. Lock), pp 358–370. John Wiley & Sons, Chichester (1982).
Hill, G.S., Willye, R.G., Miller, M. and Heptinstall, R.M. Experimental papillary necrosis of the kidney.Am. J. Pathol. 68:213 (1972).
Nagi, A.H., Alexander, F. and Barabas, A.Z. Gold nephropathy in rats — Light and electron microscopic studies.Exp. Mol. Pathol., 15:354 (1971).
Fiegelson, E.B., Drake, J.W. and Recant, L., Experimental aminonucleoside nephrosis in rats.J. Lab. Clin. Med. 50:437 (1957).
Stitzer, S.O. and Maldonado M.M., Clearance methods in the rat. In: Methods in Pharmacology, Vol 2 (ed. M.M. Maldonado) , pp 23–40. Plenum Press, New York (1978).
Biber, T. U. L., Mylle, M., Baines, A.D., Gottschalk, C. W., Oliver, J.R. and MacDowell, M.C. A study by micropuncture and microdissection of acute renal damage in rats.Amer. J. Med. 44:664–705 (1968).
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Maiza, A., Daley-Yates, P.T. (1989). Drug Pharmacokinetics in Renal Failure — Influence of Disease Type. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_59
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DOI: https://doi.org/10.1007/978-1-4757-2040-2_59
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