Nephrotoxicity pp 361-366 | Cite as

The Response of the Pig Kidney to a Combination of Cisplatin and Irradiation

  • M. E. C. Robbins
  • M. Robinson
  • M. Rezvani
  • J. W. Hopewell


Cis-dichlorodiammine platinum II, or cisplatin (c-DDP) , has become one of the principal chemotherapeutic agents in the treatment of some solid tumours, particularly testicular (1) and ovarian cancers (2) . A primary factor limiting its use is the associated nephrotoxicity (3) . The majority of patients with advance ovarian carcinoma who enter remission after treatment with cisplatin only maintain this state for a relatively short period of time. This appears to be a result of the presence of residual micro-metastic disease. Radiotherapy treatment involving the irradiation of the whole abdomen might increase the prospects of cure in these patients, but might also result in increased nephrotoxicity.


Toxicity Hydrate Depression Urea Platinum 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. E. C. Robbins
    • 1
  • M. Robinson
    • 1
  • M. Rezvani
    • 1
  • J. W. Hopewell
    • 1
  1. 1.CRC Normal Tissue Radiobiology Research Group, Research Institute, Churchill HospitalUniversity of OxfordHeadington, OxfordUK

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