Nephrotoxicity pp 361-366 | Cite as

The Response of the Pig Kidney to a Combination of Cisplatin and Irradiation

  • M. E. C. Robbins
  • M. Robinson
  • M. Rezvani
  • J. W. Hopewell

Abstract

Cis-dichlorodiammine platinum II, or cisplatin (c-DDP) , has become one of the principal chemotherapeutic agents in the treatment of some solid tumours, particularly testicular (1) and ovarian cancers (2) . A primary factor limiting its use is the associated nephrotoxicity (3) . The majority of patients with advance ovarian carcinoma who enter remission after treatment with cisplatin only maintain this state for a relatively short period of time. This appears to be a result of the presence of residual micro-metastic disease. Radiotherapy treatment involving the irradiation of the whole abdomen might increase the prospects of cure in these patients, but might also result in increased nephrotoxicity.

Keywords

Glomerular Filtration Rate Effective Renal Plasma Flow Renal Haemodynamics Advance Ovarian Carcinoma Kidney Glomerular Filtration Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. E. C. Robbins
    • 1
  • M. Robinson
    • 1
  • M. Rezvani
    • 1
  • J. W. Hopewell
    • 1
  1. 1.CRC Normal Tissue Radiobiology Research Group, Research Institute, Churchill HospitalUniversity of OxfordHeadington, OxfordUK

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