The Effect of Amiloride on Cisplatin Induced Nephrotoxicity and the Renal Uptake of (195mPt) Cisplatin in Male Wistar Rats
Cisplatin is an effective antineoplastic agent . Its clinical use is complicated by nephrotoxicity, (Goldstein et al., 1981) hypomagnesaemia and inappropriate renal magnesium wasting (Shilsky et al., 1979) . Coadministration of diuretics decreases the general nephrotoxicity, but may exacerbate the magnesium wasting. Amiloride is a potassium and magnesium sparing diuretic (Devane and Ryan, 1983) which theoretically may overcome the cisplatin induced nephrotoxicity and magnesium loss . The purpose of this study was to evaluate the effect of amiloride on:-
cisplatin induced nephrotoxicity and
renal, hepatic, plasma and urinary concentrations of (195mPt) cisplatin in male Wistar rats .
KeywordsRenal Cortex Kidney Cortex Body Weight Ratio Renal Uptake Renal Functional Impairment
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© Springer Science+Business Media New York 1989