Nephrotoxicity pp 349-351 | Cite as

Renal Toxicity of Cis-Dichlorodiammine Platinum in Rats

  • Mirian A. Boim
  • Elvino J. G. Barros
  • Luiz A. R. Moura
  • Oswaldo L. Ramos
  • Nestor Schor

Abstract

Cis-Dichlorodiammine Platinum (DDP) is an effective anticancer agent that changes the natural history of many tumours, especially testicular carcinoma. However, its use in the treatment of several kinds of solid tumours has been restricted by a high renal toxicity incidence (1–3) . Acute or chronic DDP administration in experimental models have shown an important reduction on glomerular filtration rate but, the pathophysiological mechanism of this acute renal failure (ARF) is unclear.

Keywords

Renal Plasma Flow Single Nephron Single Nephron Glomerular Filtration Rate Effective Anticancer Agent Ultrafiltration Coefficient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Mirian A. Boim
    • 1
  • Elvino J. G. Barros
    • 1
  • Luiz A. R. Moura
    • 1
  • Oswaldo L. Ramos
    • 1
  • Nestor Schor
    • 1
  1. 1.Nephrology DivisionEscola Paulista de MedicinaS O PauloBrazil

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