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Renal Toxicity of Cis-Dichlorodiammine Platinum in Rats

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Abstract

Cis-Dichlorodiammine Platinum (DDP) is an effective anticancer agent that changes the natural history of many tumours, especially testicular carcinoma. However, its use in the treatment of several kinds of solid tumours has been restricted by a high renal toxicity incidence (1–3) . Acute or chronic DDP administration in experimental models have shown an important reduction on glomerular filtration rate but, the pathophysiological mechanism of this acute renal failure (ARF) is unclear.

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Authors and Affiliations

  1. Nephrology Division, Escola Paulista de Medicina, Rua Botucatu, 740, 04023, S O Paulo, SP, Brazil

    Mirian A. Boim, Elvino J. G. Barros, Luiz A. R. Moura, Oswaldo L. Ramos & Nestor Schor

Authors
  1. Mirian A. Boim
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  2. Elvino J. G. Barros
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  3. Luiz A. R. Moura
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  4. Oswaldo L. Ramos
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  5. Nestor Schor
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Editor information

Editors and Affiliations

  1. The Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey, UK

    P. H. Bach

  2. ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK

    E. A. Lock

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© 1989 Springer Science+Business Media New York

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Boim, M.A., Barros, E.J.G., Moura, L.A.R., Ramos, O.L., Schor, N. (1989). Renal Toxicity of Cis-Dichlorodiammine Platinum in Rats. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_52

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  • DOI: https://doi.org/10.1007/978-1-4757-2040-2_52

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2042-6

  • Online ISBN: 978-1-4757-2040-2

  • eBook Packages: Springer Book Archive

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