Nephrotoxicity pp 315-323 | Cite as

Effects of Acute and Chronic Cyclosporine Administration on Glomerular Haemodynamics in Rats

  • Elvino J. G. Barros
  • Mirian A. Boim
  • Luiz A. R. Moura
  • Oswaldo L. Ramos
  • Nestor Schor


Cyclosporine (CsA) a potent immunosuppressive drug which has afforded benefit in transplantation and in the treatment of several immune-mediated diseases (1–3). However, a number of side effects have been observed, with nephrotoxicity being the most common and important (4–6). The impairment of glomerular filtration rate (GFR) and thus, acute renal failure (ARF) observed with CsA appears to be related with renal haemodynamic alterations (7,8) . No significant glomerular lesions have been found (4).


Toxicity Filtration Angiotensin Prostaglandin Cyclosporine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    B.D. Kahan, Cyclosporine: the agent and its actions, Transplant. Proc. 17:5 (1985) .PubMedGoogle Scholar
  2. 2.
    A.W. Thompson, P.H. Whiting and J.G. Simpson, Cyclosporine: immunology, toxicity and pharmacology in experimental animals, Agents. Actions. 15:306 (1984) .Google Scholar
  3. 3.
    J.F. Borel, Cyclosporine A present experimental status, Transplant. Proc. 13:344 (1981) .PubMedGoogle Scholar
  4. 4.
    S.O. Bohman, G. Klintmalm, O. Ringden, B. Sundelin and H. Welzek, Interstitial fibrosis in human kidney grafts after 12 to 46 months of cyclosporine therapy, Transplant. Proc. 17:1168 (1985).Google Scholar
  5. 5.
    S.M. Flechner, G. Van Buren, R.H. Herman and B. D. Kahan, The nephrotoxicity of cyclosporine in renal transplant recipients, Transplant. Proc. 15:2689 (1983).Google Scholar
  6. 6.
    J.M. Hows, J.M. Smith, A. Bughn and E.C. Gordon-Smith, Nephrotoxicity in marrow graft recipients treated with cyclosporine, Transplant. Proc. 15:2708 (1983) .Google Scholar
  7. 7.
    B.M. Murray, M.S. Paller and T.F. Ferris, Effect of cyclosporine administration on renal hemodynamics in conscious rats, Kidney Int. 28:767 (1985) .PubMedCrossRefGoogle Scholar
  8. 8.
    B.M. Murray and. M.S. Paller, Beneficial effects of renal denervation and prazosin on GFR and renal blood flow after cyclosporine in rats, Clin. Nephrol. 25:537 (1986) .Google Scholar
  9. 9.
    N. Perico, A. Benigni, E. Bosco, M. Possini, S. Orisio, F. Ghilardi, A. Piccinelli and G. Remuzzi, Acute cyclosporine nephrotoxicity in rats: which role for renin-angiotensin system and glomerular prostaglandin?, Clin. Nephrol. 25:583 (1986).Google Scholar
  10. 10.
    N. Schor, I. Ichikawa, H.G. Rennke, J.L. Troy and B.M. Brenner, Pathophysiology of altered glomerular function in aminoglycoside-treated rats, Kidney Int . 19:288 (1981) .PubMedCrossRefGoogle Scholar
  11. 11.
    B.D. Myers, J. Ross, L. Newton, J. Luetscher and M. Pelroth, Cyclosporine associated chronic nephropathy, N. Engl. J. Med. 311:699 (1984) .PubMedCrossRefGoogle Scholar
  12. 12.
    N. Schor, I. Ichikawa and B.M. Brenner, Mechanism of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat, Kidney Int . 20:442 (1981) .PubMedCrossRefGoogle Scholar
  13. 13.
    R.C. Blantz, K.S. Konnen and B.J. Tucker, Angiotensin II effect upon the glomerular microcirculation and ultrafiltration coefficient on the rat, J. Clin. Invest. 57:419 (1976).PubMedCrossRefGoogle Scholar
  14. 14.
    H. Siegel, B. Ryffel, P. Petric, P. Shoemaker, A. Muller, P. Donatsch and M. Mihatsch, Cyclosporine, the renin-angiotensin system, and renal adverse reactions, Transplant. Proc. 15:2719 (1983).Google Scholar
  15. 15.
    C.R. Baxter, G.G. Duggin, B.M. Hall, J.S. Harvath and D.J. Tiller, Stimulation of renin release from rat renal cortical slices by cyclosporine A, Res. Com. Chem. Pathol. Pharmacol. 43:417 (1984).Google Scholar
  16. 16.
    R.E. McCaa, J.E. Hall and C.S. McCaa, The effects of angiotensin I converting enzyme inhibition on arterial blood pressure and urinary sodium excretion. Role of the renal renin-angiotensin and kallikrein-kinin system, Circ. Res. 43:132 (1978).Google Scholar
  17. 17.
    J.F. Gerken, S.B. Bhgwandeen, P.J. Dosen and A.J. Smith, The effect of salt intake on cyclosporine-induced impairment of renal function in rats, Transplantation 38:412 (1984).CrossRefGoogle Scholar
  18. 18.
    D. Adu, C.J. Lote, J. Michael, J. H. Turney and P. McMaster, Does cyclosporine inhibit renal prostaglandin synthesis? Proc. EDTA-ERA 21:969 (1984) .Google Scholar
  19. 19.
    M.S. Palier and B.M. Murray, Renal dysfunction in animal model of cyclosporine toxicity, Transplant. Proc. 17 :155 (1985).Google Scholar
  20. 20.
    B. Ryffel, P. Dontsch, P. Hiestand and M. J. Mihatsch, PGE2 reduces nephrotoxicity and immunosupression of cyclosporine in rats, Clin. Nephrol. 21:595 (1986) .Google Scholar
  21. 21.
    A. Iaina, D. Herzog, D. Cohen, S. Gavendo, S. Kapuler, I. Serban, G. Schiby and H.E. Eliahou, Calcium entry-blockade with verapamil in cyclosporine A plus ischemia-induced acute renal failure in rats, Clin. Nephrol. 25:S168 (1986) .Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Elvino J. G. Barros
    • 1
  • Mirian A. Boim
    • 1
  • Luiz A. R. Moura
    • 1
  • Oswaldo L. Ramos
    • 1
  • Nestor Schor
    • 1
  1. 1.Nephrology DivisionEscola Paulista de MedicinaS O PauloBrazil

Personalised recommendations