The Effect of Biliary Cannulation or Ligation on Cyclosporin A (CsA) Nephrotoxicity in The Rat
Although Cyclosporin A (CsA) has become widely accepted as the agent of choice for the control of organ allograft rejection, its attendant nephrotoxicity may still limit its clinical use (Flechner et al, 1983). This property of CsA has, to date, restricted its evaluation as an immunotherapeutic agent in areas of clinical medicine other than transplanation (eg autoimmune disorders). This nephrotoxicity is characterised in both animals and man by a reduction in glomerular filtration rate and by structural damage to the renal proximal tubules (Mihatsch et al, 1985; Blair et al, 1982; Thomson et al, 1984). The pathogenesis of CsA-induced nephrotoxicity, however remains unclear as does the identity of the toxic species, be it parent molecule and/or a metabolite (s).
KeywordsAspartate Transaminase Biliary Cannulation Hepatic Drug Metabolism Creatinine Clearance Rate Ligation Group
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