Nephrotoxicity pp 285-290 | Cite as
The Effects of Cyclosporin a on the Urine Excretion of Specific Proteins in Humans
Abstract
Cyclosporin A (CyA) is widely used as an immunosuppressant following organ transplantation and in the treatment of various autoimmune disorders. A major disadvantage is its nephrotoxicity which is probably of multifactorial origin, involving acute, reversible haemodynamic changes and irreversible tubulointerstitial injury and focal glomerulosclerosis (Cohen et al, 1984; Klintmalm et al, 1984; Myers et al, 1984; Palestine et al, 1986). There is no satisfactory animal model for CyA nephrotoxicity and its assessment in CyA treated renal transplant recipients is complicated by the coexistence of other renal disorders. For these reasons, we have chosen to study a group of patients being treated with long-term CyA for an autoimmune disorder, primary biliary cirrhosis (PBC).
Keywords
Primary Biliary Cirrhosis Retinol Binding Protein Tubular Proteinuria Serum Retinol Binding Protein Focal GlomerulosclerosisPreview
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References
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