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Nephrotoxicity pp 285-290 | Cite as

The Effects of Cyclosporin a on the Urine Excretion of Specific Proteins in Humans

  • Anne Dawnay
  • Michael Lucey
  • Carolyn Thornley
  • Robert Beetham
  • Bill Cattell
  • Roger Williams
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Abstract

Cyclosporin A (CyA) is widely used as an immunosuppressant following organ transplantation and in the treatment of various autoimmune disorders. A major disadvantage is its nephrotoxicity which is probably of multifactorial origin, involving acute, reversible haemodynamic changes and irreversible tubulointerstitial injury and focal glomerulosclerosis (Cohen et al, 1984; Klintmalm et al, 1984; Myers et al, 1984; Palestine et al, 1986). There is no satisfactory animal model for CyA nephrotoxicity and its assessment in CyA treated renal transplant recipients is complicated by the coexistence of other renal disorders. For these reasons, we have chosen to study a group of patients being treated with long-term CyA for an autoimmune disorder, primary biliary cirrhosis (PBC).

Keywords

Toxicity Albumin Urea Creatinine Bilirubin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Anne Dawnay
    • 1
    • 2
  • Michael Lucey
    • 1
    • 2
  • Carolyn Thornley
    • 1
    • 2
  • Robert Beetham
    • 1
    • 2
  • Bill Cattell
    • 1
    • 2
  • Roger Williams
    • 1
    • 2
  1. 1.Departments of Chemical Pathology and Nephrology, St Bartholomew’s Centre for ResearchSt Bartholomew’s HospitalLondonUK
  2. 2.The Liver UnitKing’s College HospitalLondonUK

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