Amphotericin-B Nephrotoxicity is Decreased by Intravenous Flucytosine in the Rat
Amphotericin-B is the most useful drug of the treatment of systemic mycotic infections. The clinical use however is limited because of the side effect to cause nephrotoxicity. The mechanisms by which amphotericinB induced renal impairment are not yet known. Since the acute vascular effects of amphotericin-B on the kidney can be ameliorated by sodium chloride loading, furosemide and aminophylline, it has been suggested that amphotericin-B activates the tubular glomerular feed-back (Gerkens and Branch, 1980; Heidemann et al., 1983). The antifungal efficacy of the treatment can be increased by a combination of amphotericin-B plus flucytosine (Bennett et al., 1979). Intravenous flucytosine is dissolved in saline. It was therefore the aim of this study to investigate the effect of flucytosine on amphotericin-B nephrotoxicity.
KeywordsCreatinine Clearance Cryptococcal Meningitis Renal Tubular Acidosis Potassium Excretion Serum Sodium Concentration
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