The present study considers a chronobiological approach in optimizing the clinical use of a drug know to induce nephrotoxicity, amikacin. Nephrotoxicity is probably the most frequent untoward effect encountered in patients treated with aminoglycoside antibiotics. Kidney dysfunction induced by these drugs primarily results from acute tubular necrosis. The risk of morbidity may be further aggravated by the widespread use of aminoglycosides such as advanced age, hypovolaemia, renal disease, previous treatment with aminoglycosides or concomitant administration of other nephrotoxic substances. Other factors may interfere such as dose, duration of drug treatment, frequency and time of administration (Fillastre, 1986). The aim of this study is to determine the importance of the latter.
KeywordsBrush Border Membrane Acute Tubular Necrosis Aminoglycoside Antibiotic Kidney Dysfunction Brush Border Enzyme
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