Morphological and Functional Effects in Rat Neonates of Aminoglycosides Given to the Mother During Gestation
Aminoglycosides are widely used to treat gram-negative infections, which occur frequently in pregnant women and require the use of these antibiotics. The nephrotoxicity of aminoglycosides is an important consideration in the clinical use of these drugs, that has led to numerous studies (Price, 1986). However, little attention has been paid to a possible nephrotoxic effect of these antibiotics on the foetus, although they are able to cross the placental barrier.
KeywordsGlomerular Basal Membrane Anionic Site Proximal Tubule Cell Nephrotoxic Effect Lamina Densa
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