Morphological and Functional Effects in Rat Neonates of Aminoglycosides Given to the Mother During Gestation
Aminoglycosides are widely used to treat gram-negative infections, which occur frequently in pregnant women and require the use of these antibiotics. The nephrotoxicity of aminoglycosides is an important consideration in the clinical use of these drugs, that has led to numerous studies (Price, 1986). However, little attention has been paid to a possible nephrotoxic effect of these antibiotics on the foetus, although they are able to cross the placental barrier.
KeywordsToxicity Creatinine Polyethylene Glycoside Gentamicin
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- Bakala H., Cornet S., Cheignon M., Djaziri R. and Schaeverbeke J., 1987, Basement Membrane Proteoglycans and Anionic Sites in the Fetal Rat Kidney during Late Gestation. J. Morphol. (to be published).Google Scholar
- Cheignon M., Bakala H., Cornet S., Djaziri R. and Schaeverbeke J., 1987, Localization of Basement Membranes Glycoproteins in the Rat Kidney during Fetal Development. Biol. Cell., 60: (to be published).Google Scholar
- Mallie, J.P., Gerard H. and Gerard A., 1985, Developing kidney and inutero exposure to gentamicin, in: “Renal Heterogeneity and Target Cell Toxicity, P.H. Bach and E.A. Lock eds., John Wiley & Sons, Chichester, pp 365–368.Google Scholar
- Mallie, J.P., Gerard H. and Gerard A., 1986, In-utero Gentamicin-lnduced Nephrotoxicity in Rats. Fediatr. Pharmacol., 5:229–239.Google Scholar
- Mallie, J.P., Coulon G., Billerey Cl. and Faucourt A., 1987, In-utero Induced Aminoglycosides Nephrotoxicity in Rat Neonates. Kidney International (accepted).Google Scholar
- Stolte H. and Alt J.M., 1982, The choice of animals for nephrotoxic investigations, In: “Nephrotoxicity, Assessment and Pathogenesis”, P.H. Bach et al., eds., John Wiley & Sons, Chichester, pp 102–112.Google Scholar
- Weinberg E.H., Fleld W.E., Gray W.D., Klein M.F., Robbins G.R. and Schwartz E., 1981, Preclinical Toxicologic Studies of Netilmicin. Arzneim Forsch. Drug Res., 31: 816–822.Google Scholar