Nephrotoxicity pp 233-239 | Cite as

Morphological and Functional Effects in Rat Neonates of Aminoglycosides Given to the Mother During Gestation

  • J. P. Mallie
  • H. Smaoui
  • Cl. Billerey
  • M. Cheignon
  • J. Schaeverbke


Aminoglycosides are widely used to treat gram-negative infections, which occur frequently in pregnant women and require the use of these antibiotics. The nephrotoxicity of aminoglycosides is an important consideration in the clinical use of these drugs, that has led to numerous studies (Price, 1986). However, little attention has been paid to a possible nephrotoxic effect of these antibiotics on the foetus, although they are able to cross the placental barrier.


Toxicity Creatinine Polyethylene Glycoside Gentamicin 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. P. Mallie
    • 1
  • H. Smaoui
    • 2
  • Cl. Billerey
    • 3
  • M. Cheignon
    • 2
  • J. Schaeverbke
    • 2
  1. 1.Lab. de NephrologieUniversite NancyVandoeuvre CedexFrance
  2. 2.Lab. de Biologie CellulaireUniversite Paris 7Paris Cedex 05France
  3. 3.Lab. d’Anatomie PathologiqueBesancon CedexFrance

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