Nephrotoxicity pp 225-231 | Cite as

Morphological and Functional Impairment of the Developing Rat Kidney Exposed to Gentamicin in Utero

  • Thierri Gilbert
  • Martine Lelievre-Pegorier
  • Bernadette Nabarra
  • Claudie Merlet-Benichou


Aminoglycoside antibiotics used to treat severe bacterial infection during pregnancy can cross the placenta. The effects of in utero exposure to these compounds is receiving increasing attention. It was shown that in the foetal animal, as in the adult, the kidney was the major site of gentamicin accumulation (1). In foetal guinea-pigs whose mothers were given daily 4 mg/kg of gentamicin for the seven days immediately following the period of nephrogenesis, intrarenal gentamicin concentration was found to be about 2 ug/g of tissue. More than two weeks after the treatment to the mother has ceased, the antibiotic released from all maternal and foetal tissues continued to accumulate in the developing kidney, especially as the renal blood flow and glomerular filtration rate increased with age (2). In pups born of gentamicin-treated mothers, impairments of the growth and the function of the proximal tubules were observed, but the damage was transitory (2).


Phosphorus Filtration Urea Citrate Epoxy 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Thierri Gilbert
    • 1
  • Martine Lelievre-Pegorier
    • 1
  • Bernadette Nabarra
    • 2
  • Claudie Merlet-Benichou
    • 1
  1. 1.INSERM U13Hopital Claude BernardParis CEDEX 19France
  2. 2.INSERM U25 and CNRS LA122Hopital Necker-Enfants MaladesParisFrance

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