Abstract
While furosemide (F), a potent loop diuretic, has been known to potentiate gentamicin (G) nephrotoxicity (1), verapamil (V), a calcium entry blocker, has been postulated to attenuate gentamicin nephrotoxicity (2). We have therefore examined the effect of furosemide or verapamil co-administration with gentamicin on renal gentamicin accumulation.
Chapter PDF
Similar content being viewed by others
Keywords
- Renal Cortex
- Proximal Tubular Cell
- Calcium Entry Blocker
- Aminoglycoside Nephrotoxicity
- Proximal Tubular Damage
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
R.D. Adelman, W.L. Splanger, F. Beasom, G. Ishizaki and G.N. Conzelman. Furosemide enhancement of experimental gentamicin nephrotoxicity; comparison of functional and morphorogical changes with activities of urinary enzyme. J. Infect. Dis. 140:342 (1979)
H. Eliahou, A. Iaina, I. Serbon, S. Gaveno and S. Kapuler. Verapamil’s beneficial effect and cyclic nucleosides in gentamicin-induced acute renal failure (ARF) in rats (abstract). Proc. IX Int. Cong. Nephrol. 323A (1984)
Y. Orita, Y. Fukuhara, H. Nakahama, M. Horio, T. Moriyama and T. Kamada. Enhanced nephrotoxicity of gentamicin by furosemide. In: Diuretics II. Chemistry, Pharmacology and Clinical Applications . J.B. Puschett ed. , Elsevier Science Publishing Co. Inc. New York. (1987)
T.J. Burke, P.E. Arnold, J.A. Gordon, R.E. Bulger, D.C. Dobyan and R.W. Schrier. Protective effect of intrarenal membrane blockers before or after renal ischemia. J. Clin. Invest. 74: 1830 (1984)
D.C. Harris, W.S . Harnond, T.J. Burke and R.W. Schrier. Verapamil protects against progression of experimental chronic renal failure. Kidney Int 31: 41 (1987)
R.E. Cronin, K.L. Nix, E.R. Ferguson, P.M. Southern and W.L. Henrich. Renal cortex ion composition and Na-K ATPase activity in gentamicin nephrotoxicity. Am. J. Physiol. 242:F477 (1982)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nakahama, H., Horio, M., Moriyama, T., Fukuhara, Y., Orita, Y., Kamada, T. (1989). Effect of Furosemide and Verapamil on Gentamicin Nephrotoxicity. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_31
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2040-2_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-2042-6
Online ISBN: 978-1-4757-2040-2
eBook Packages: Springer Book Archive