Possible Role of the Renin-Angiotensin System in the Development of Gentamicin Nephrotoxicity in the Rat
The possible involvement of the renin angiotensin system in the development of drug induced renal failure was investigated by inhibiting the activity of Angiotensin Converting Enzyme (ACE) with Perindopril, a new specific and potent inhibitor of ACE (1). The anti-hypertensive activity of Perindopril is similar to that of Ramipril and greater than that of Enalapril (2). The pattern of gentamicin induced kidney damage is now well established (3,4) and thus allowed the use this drug to produce a model of drug induced renal failure with proximal tubule injury. This study was performed in Wistar rats and consisted of the evaluation of renal morphological, biochemical and functional parameters.
KeywordsToxicity Filtration Cage Creatinine Bacillus
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