Nephrotoxicity pp 201-206 | Cite as

Silymarin Ameliorates Gentamicin Nephrotoxicity

  • M. K. Chan
  • W. L. Ng


Gentamicin (GM) nephrotoxicity is most evident in the proximal tubules which sustain injury as a result of membrane-related events (1–3). Silymarin (SL), an extract from the plant milk thistle, has been shown to exert membrane protective effects (4). The possibility that silymarin may prevent or ameliorate GM-induced nephrotoxicity is investigated in a rat model.


Toxicity Peroxide Hepatitis Cage Creatinine 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. K. Chan
    • 1
  • W. L. Ng
    • 2
  1. 1.Department of MedicineUniversity of Hong KongChina
  2. 2.Department of Pathology, Queen Mary HospitalUniversity of Hong KongHong KongChina

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