Nephrotoxicity pp 171-175 | Cite as

Lithium-Induced Distal Nephron Dilatation in Young Rabbits With Associated Encephalitazoan Cuniculi Related Interstitial Fibrosis

  • C. J. Roe
  • R. G. Walker
  • P. K. Kincaid-Smith

Abstract

Controversy exists over whether interstitial fibrosis occurs as a consequence of chronically administered lithium. Our group in a previous study (1) using adult NZW rabbits demonstrated the presence of both interstitial nephritis and distal tubular dilatation (microcyst formation) following 12 months lithium chloride administration. The present study was conducted in order to confirm these results and in particular to try to further explore the rabbit as an animal model of renal cystic disease. In this study however, young rabbits were used to examine any potentiating effect of lithium on the developing kidney.

Keywords

Interstitial Fibrosis Distal Tubule Interstitial Nephritis Young Rabbit Renal Cystic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    R.G. Walker, M. Escott, I. Birchall, J.P. Dowling, P. Kincaid-Smith, Chronic progressive renal lesions induced by lithium, Kidney Intern. 29:865–881 (1986) .CrossRefGoogle Scholar
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    T.H. Mathew, D.C. Mathews, J.B. Hobbs, P. Kincaid-Smith, Glomerular lesions after renal transplantation, Am. J. Med. 59:177–190 (1975).PubMedCrossRefGoogle Scholar
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    J.C. Cox, H.A. Gallichio, An evaluation of indirect immunof luorescence in the serological diagnosis of Nosema cuniculi infection, Res. Vet. Sci. 22:50–52 (1977).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • C. J. Roe
    • 1
  • R. G. Walker
    • 1
  • P. K. Kincaid-Smith
    • 1
  1. 1.Department of NephrologyThe Royal Melbourne HospitalParkvilleAustralia

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