Lithium-Induced Distal Nephron Dilatation in Young Rabbits With Associated Encephalitazoan Cuniculi Related Interstitial Fibrosis
Controversy exists over whether interstitial fibrosis occurs as a consequence of chronically administered lithium. Our group in a previous study (1) using adult NZW rabbits demonstrated the presence of both interstitial nephritis and distal tubular dilatation (microcyst formation) following 12 months lithium chloride administration. The present study was conducted in order to confirm these results and in particular to try to further explore the rabbit as an animal model of renal cystic disease. In this study however, young rabbits were used to examine any potentiating effect of lithium on the developing kidney.
KeywordsInterstitial Fibrosis Distal Tubule Interstitial Nephritis Young Rabbit Renal Cystic Disease
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