Nephrotoxicity of Uranyl Fluoride and Reversibility of Renal Injury in the Rat
Recent accidental exposures of workers and members of the public to uranium hexafluoride (UF6) releases have reinforced interest in the nephrotoxic properties of uranium compounds (1). Additionally, a large industrial work force is engaged in several types of uranium production operations in which intermittent exposures frequently occur. Despite recent improvements in our understanding of the toxicology and biokinetics of uranium, there remain several important issues for which there are virtually no occupational or experimental data. Foremost of these issues is the time course and extent to which nephrotoxic actions of uranyl uranium are reversible, particularly after exposures at or near the socalled threshold for injury of 3 ug U/g kidney (2–5). More-over, better procedures for detecting uranium-induced renal injury need to be identified, particularly for injury associated with exposure to occupationally relevant uranium compounds. The objective of the present study was to examine severity and duration of renal injury produced in the rat from exposures to low levels of uranyl fluoride (UO2F2).
KeywordsHydrolysis Albumin Lactate Cage Creatinine
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