Nephrotoxicity pp 103-106 | Cite as

Prevention and Reversal of Mercuric Chloride-Induced Increases in Renal Vascular Resistance by Captopril

  • Z. H. Endre
  • L. G. Nicholls
  • P. J. Ratcliffe
  • J. G. G. Ledingham

Abstract

By inducing ischaemia, changes in renal vascular resistance (RVR) may contribute substantially to the extent of nephrotoxic injury. The in vitro perfused rat kidney (IPRK) allows changes in RVR to be monitored precisely following nephrotoxin exposure. Mercuric chloride causes dose-dependent increases in RVR in filtering perfused rat kidneys (1) . We have examined the prevention and/or reversibility of these alterations in RVR by hydralazine, verapamil and captopril.

Keywords

Perfusion Pressure Mercuric Chloride Renal Vascular Resistance Sulphydryl Group Acute Rise 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Z .H. Endre, P .J. Ratcliffe, L.G. Nicholls, J.G.G. Ledingham, J.D. Tange and G.K. Radda, 31PNMR studies of mercuric chloride nephrotoxicity in the in vitro perfused rat kidney, (this Symposium).Google Scholar
  2. 2.
    P .J. Ratcliffe, Z .H. Endre, L.G. Nicholls, J.D. Tange and J.G.G. Ledingham, The isolated perfused rat kidney: filtering and non-filtering models in the assessment of altered renal vascular resistance in nephrotoxicity, (this Symposium).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Z. H. Endre
    • 1
  • L. G. Nicholls
    • 1
  • P. J. Ratcliffe
    • 1
  • J. G. G. Ledingham
    • 1
  1. 1.Nuffield Department of Clinical Medicine, John Radcliffe HospitalUniversity of OxfordOxfordUK

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