In Vitro and in Vivo HgCl₂-Induced Nephrotoxicity Assessed by Tubular Enzymes Release

Abstract

The assessment of the nephrotoxicity in clinical practice, as in experimental setting, was based largely on the determination of changes in haemodynamic parameters and electrolytes excretion. However, the acute tubular necrosis involved in many forms of toxic nephropathy is frequently detected and quantified by the evaluation of the urinary activity of marker enzymes form various segments of the nephron. Enzymuria has been shown to be an early and are much a more sensitive index of tubular damage than haemodynamic or electrolyte changes (Price, 1982).