Nephrotoxicity pp 711-718 | Cite as

Age-Related Changes in Renal Brush Borders and Brush Border Enzymes

  • Masatoshi Nakano


The ageing process leads to a deterioration of function in most body organs. Much attention has been paid to studying the effect of ageing on the kidney. These changes are both structural and functional. Thus far, the structural changes of kidney during ageing has been extensively studied (1,2), the number of glomeruli decreasing with age. The progressive thickening of the tubular and glomerular basement membrane occurs with the ageing process (1,2). Tauchi and his associates (2,3) have morphologically demonstrated that the number of tubular epithelial cells decrease with age.


Filtration Electrophoresis Leucine Maltose Nephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R. Goldman, Aging of the excretory system: kidney and bladder. In: “Handbook of the Biology of Aging”, C.E. Hayflick, eds. Van Nostrand Reinhold Ltd., New York, pp 409–431 (1977).Google Scholar
  2. 2.
    H. Tauchi, “Morphology of Aging”, Rikogakusha, Tokyo (1980)Google Scholar
  3. 3.
    H. Tauchi, K. Tsuboi, and J. Okutomi, Age changes in the human kidney of different races. Gerontoloqia, 17:87–97 (1971).CrossRefGoogle Scholar
  4. 4.
    D.F. Davies and N.H. Shock, Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J. Clin. Invest. 29:496–507 (1950).PubMedCrossRefGoogle Scholar
  5. 5.
    J.H. Miller, R.K. McDonald, and N.W. Shock, Age changes in the maximal rate of renal tubular reabsorption of glucose. J. Gerontol. 7:196–200 (1952).PubMedCrossRefGoogle Scholar
  6. 6.
    CM. Kiebzak and B. Sacktor, Effect of age on renal conservation of phosphate in the rat. Am. J. Phvsiol. 251:F399-F407 (1986)Google Scholar
  7. 7.
    M. Nakano, Y. Ito, K. Kohtani, T. Mizuno, and H. Tauchi, Age-related change in brush borders of rat kidney cortex. Mech. Aging Dev. 33:95–102 (1985).PubMedCrossRefGoogle Scholar
  8. 8.
    J. Pratz and B. Corman, Age-related changes in enzyme activities, protein content and lipid composition of rat kidney brush border membrane. Biochim. Biophvs. Acta, 814:265–273 (1985).CrossRefGoogle Scholar
  9. 9.
    U. Reiss and B. Sacktor, Alteration of kidney brush border membrane maltase in aging rats. Biochim. Biophvs. Acta, 704:422–426 (1982).CrossRefGoogle Scholar
  10. 10.
    M. Rothstein, Age-related changes in enzyme levels and enzyme properties. In: “Review of Biological Research in Aging”, M. Rothstein, ed. vol. 2, A.B. Liss, Inc., New York, pp 421–433 (1985).Google Scholar
  11. 11.
    D. Gershon, Current status of age-altered enzymes: Alternative mechanism, Mech. Ageing Dev., 9:189–196 (1979).PubMedCrossRefGoogle Scholar
  12. 12.
    M. Nakano and H. Tauchi, Age-related alteration of renal brush border leucine aminopeptidase in rat kidney cortex. Mech. Ageing Dev., submitted for publication.Google Scholar
  13. 13.
    D. 0’Bryan and L.M. Lowenstein, Effect of aging on renal membrane-bound enzyme activities. Biochim. Biophvs. Acta, 339:1–9 (1974).CrossRefGoogle Scholar
  14. 14.
    U. Reiss and B. Sacktor, Monoclonal antibodies to renal brush border membrane maltase: Age-associated antigenic alterations. Proc. Natl. Acad. Sci., U.S., 80:3255–3259 (1983).CrossRefGoogle Scholar
  15. 15.
    CM. McCay, L.A. Maynard, G. Sperling and L.L. Barnes, Retarded growth, life span, ultimate body size and age changes in the albino rat after feeding diets restricted in calories. J. Nutr. 18:1–18 (1939)Google Scholar
  16. 16.
    M. Nakano, H. Taauchi, K. Kohtani, T. Mizuno, Y. Ito, and H. Tauchi, Age-related change of renal tubular brush border enzymes in different nutritional conditions. Biomed. Gerontol. 11:131–132 (1987).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Masatoshi Nakano
    • 1
  1. 1.Institute for Medical Science of AgeingAichi Medical UniversityNagakute, Aichi-kenJapan

Personalised recommendations