Urine Glutathione-S-Transferase Associated with Nephrotoxic Drugs
Administration of a large number of therapeutic and diagnostic agents is associated with injury to the renal tubules. We have studied the appearance of glutathione-S-transferase (GST) in the urine as a marker of renal tubular injury. GST is a cytosolic enzyme found in kidney, liver, and small intestine (1). It binds many substances and catalyses the conjugation of some of its ligands to reduced glutathione (2,3). GST is abundant in cytosol (4) and is localized to the proximal nephron (5). Normally undetectable in urine or serum by enzymatic assay (6), GST appears in the urine in experimental tubular toxicity from substances such as mercury, chromium, and gentamicin (7,8). In this study we looked at urinary GST in rats and man following the administration of cisplatin, cyclosporin, and iodinated radiocontrast agents.
KeywordsPlasma Creatinine Acute Tubular Necrosis Urine Osmolality Nephrotoxic Drug Urinary Enzyme
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