Nephrotoxicity pp 651-657 | Cite as

Renal Haemodynamics and Renin Response During Acute Hypercapnea in Dogs

  • Hideo Fujii
  • Tetsuo Mitsuyama
  • Youji Nakashima
  • Reizo Kusukawa

Abstract

Renal haemodynamics are related to the amount of carbon dioxide inhaled. In respiratory acidosis 5% CO2 inhalation increases renal blood flow (RBF) and renal plasma flow (RPF), whereas RBF and RPF decreased after inhalation of 15% CO2. Recently, it was found that plasma renin activity (PRA) increased during acute respiratory acidosis. The PRA levels increased during both 5% CO2 and 15% CO2 inhalation (1). An extensive literature has developed concerning renin-angiotensin control systems. Three major factors, the intrarenal baroreceptors, the macula densa and the sympathetic nervous system are capable of altering renin secretion under given experimental condition.

Keywords

Plasma Renin Activity Renal Blood Flow Renal Plasma Flow Respiratory Acidosis Renin Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    H. Fujii and J. E. Zehr, The effects of respiratory acidosis on plasma renin activity in the dogs, Jpn. Cir. J. 39: 1115–1121, (1975).CrossRefGoogle Scholar
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    R. W. Gotshall, J. O. Davis, E. W. Shade, W. Spielman, J.A. Johnson and B. Breverman, Effects of renal denervation on renin release in sodiumdepleted dogs, Am. J. Physiol. 225:344–349, (1973).PubMedGoogle Scholar
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    R. T. Witty, J. O. Davis, J. A. Johnson and R. Prewitt, Effects of papaverine and hemorrhage on renin secretion in the non-filtering kidney, Am. J. Physiol. 221: 1666–1671, (1971).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Hideo Fujii
    • 1
  • Tetsuo Mitsuyama
    • 1
  • Youji Nakashima
    • 1
  • Reizo Kusukawa
    • 1
  1. 1.Department of Internal MedicineYamaguchi University School of MedicineUbe, Yamaguchi 755Japan

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