Tubulin as a G Protein?
GTP binding proteins in the synaptic membrane appear to mediate several receptor induced processes. These processes and the G-proteins mediating them include the stimulation [Gs] and inhibition [Gi] of adenylate cyclase, the gating of K+ [Gi] and Ca++ channels and the activation of phospholipase c [G?]. Several other processes might be G protein mediated as well, but the identity of the specific G proteins involved has not been determined. For many of these G proteins, the amino acid sequence and the nature of gene coding for that protein have been established. Furthermore, the tertiary structure of some is known or surmised and specific molecular domains have been suggested to participate in various aspects of G protein function.
KeywordsAdenylate Cyclase Microtubule Assembly Synaptic Membrane Tubulin Dimer Adenylate Cyclase System
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