Mathematic Modeling for Apheresis Procedures; Advantages and Limitations

  • J. P. Hester
  • J. Ventura
Part of the Developments in Hematology and Immunology book series (DIHI, volume 22)

Abstract

For most of the 25 year history of apheresis, the collection of cell components from normal donors and removal of pathologic cells or plasma factors from patients relied on operator expertise in manually performed procedures The lack of standardization of the procedures and the great variability in outcome often resulted in nonreproducible and noncomparable component yields. Automation of apheresis devices displaced some of the influence of manual operation and established reproducibility of blood processing, though automaticity alone was not sufficient to guarantee optimal component collection [1]. Subsequently, efforts to predict yields from normal donors processed on continuous flow blood cell separation devices (COBE 2997, Fenwal CS3000, COBE Spectra) was shown to be feasible using donor biologic and procedure information, thus adding some degree of predictability to automaticity [2]. Predictability of yield also requires that procedure parameters be performed in some reproducible manner.

Keywords

Platelet Rich Plasma Blood Flow Rate Procedure Parameter Calcium Gluconate Ionize Calcium Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hester JP, Ventura GJ. Modeling of platelet concentrate yield in continuous flow cell separating devices. J Clin Apheresis. In press, 1989.Google Scholar
  2. 2.
    Hester JP. Plateletpheresis techniques: Including a comparison of the efficiency of different machines. Plasma Ther Transfu Technol 1982; 3: 293–300.Google Scholar
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    Hester JP, Kellogg RM, Mulzet AP, Freireich EJ. Continuous flow techniques for platelet concentrate collection: A step toward standardization and yield predictability. J Clin Apheresis 1985; 2: 224.PubMedCrossRefGoogle Scholar
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    Hester JP, Ventura GJ. Extracorporeal anticoagulation with citrate for apheresis. In: Pineda AA, Valbonesi M, Sniecinski IJ (eds). Wichtig Editore Milan 1989: 417.Google Scholar
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    Hester JP, Ventura GJ, Boucher T. Platelet concentrate collection using computer generated algorithms for collection and prediction of yield. Plasma Ther Transfu Technol 1987; 8: 377–85.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. P. Hester
  • J. Ventura

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