Mathematic Modeling for Apheresis Procedures; Advantages and Limitations

  • J. P. Hester
  • J. Ventura
Part of the Developments in Hematology and Immunology book series (DIHI, volume 22)


For most of the 25 year history of apheresis, the collection of cell components from normal donors and removal of pathologic cells or plasma factors from patients relied on operator expertise in manually performed procedures The lack of standardization of the procedures and the great variability in outcome often resulted in nonreproducible and noncomparable component yields. Automation of apheresis devices displaced some of the influence of manual operation and established reproducibility of blood processing, though automaticity alone was not sufficient to guarantee optimal component collection [1]. Subsequently, efforts to predict yields from normal donors processed on continuous flow blood cell separation devices (COBE 2997, Fenwal CS3000, COBE Spectra) was shown to be feasible using donor biologic and procedure information, thus adding some degree of predictability to automaticity [2]. Predictability of yield also requires that procedure parameters be performed in some reproducible manner.


Platelet Rich Plasma Blood Flow Rate Procedure Parameter Calcium Gluconate Ionize Calcium Level 
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© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. P. Hester
  • J. Ventura

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