Structure-Function Relationships in Cellular and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases

  • Tony Pawson
  • Peter Greer
  • Michael Moran
  • Kelly Meckling-Hansen
  • Angela Brooks-Wilson
  • Ivan Sadowski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 234)


A majority of retroviral oncogenes encode protein-tyrosine kinases (PTKs). Both oncogenic PTKs and their normal counterparts can be divided into two classes: receptor-like polypeptides that possess an extracellular region linked by a transmembrane segment to an internal catalytic domain, and cytoplasmic PTKs that are entirely confined to the inside of the cell (see fig. 1). Cytoplasmic PTKs are usually found in association with the plasma membrane and cytoskeleton (Rohrschneider and Gentry, 1984). The cytoplasmic PTKs can be further subdivided into 3 families corresponding to a group of proteins of approximately 60 kDa for which p6Osrc is the prototype, fps/fes gene products, and abl proteins respectively (Hunter and Cooper, 1985).


Catalytic Domain Chicken Embryo Fibroblast Protein Kinase Catalytic Domain Noncatalytic Domain Decrease Kinase Activity 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Tony Pawson
    • 1
  • Peter Greer
    • 1
  • Michael Moran
    • 1
  • Kelly Meckling-Hansen
    • 1
  • Angela Brooks-Wilson
    • 1
  • Ivan Sadowski
    • 1
  1. 1.Division of Molecular and Developmental BiologyMt. Sinai Hospital Research InstituteTorontoCanada

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