Abstract
A majority of retroviral oncogenes encode protein-tyrosine kinases (PTKs). Both oncogenic PTKs and their normal counterparts can be divided into two classes: receptor-like polypeptides that possess an extracellular region linked by a transmembrane segment to an internal catalytic domain, and cytoplasmic PTKs that are entirely confined to the inside of the cell (see fig. 1). Cytoplasmic PTKs are usually found in association with the plasma membrane and cytoskeleton (Rohrschneider and Gentry, 1984). The cytoplasmic PTKs can be further subdivided into 3 families corresponding to a group of proteins of approximately 60 kDa for which p6Osrc is the prototype, fps/fes gene products, and abl proteins respectively (Hunter and Cooper, 1985).
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References
Ariizumi, K., and Shibuya, M., 1985, Construction and biological analysis of deletion mutants of Fujinami sarcoma virus: 5’-fps sequence has a role in the transforming activity, J. Virol., 55: 660.
Brugge, J.S., Cotton, P.C., Queral, A.E., Barrett, J.N., Nonner, D., and Keane, R.W., 1985, Neurones excpress high levels of a structurally modified, activated form of p60 src, Nature, 316: 554.
Chen, L.-H., Hatada, E., Wheatlej1525W., and Lee, W.-H., 1986, Single amino acid substitution from glu to asp, of the fps oncogenic protein causes temperature sensitivity in transformation and kinase activity, Virology, 155: 106.
DeClue, J., Sadowski, I., Martin, G.S., and Pawson, T., 1987, A conserved domain regulates interactions of the v-fps protein-tyrosine with the host cell, Proc. Natl. Acad. Sci. USA, In Press.
Feldman, R.A., Gabrilove, J.L., Tam, J.P., Moore, M.A.A., and Hanafusa, H., 1985, Specific expression of the normal celluar fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells, Proc. Natl. Acad. Sci, USA, 82: 2379.
Foster, D.A., and Hanafusa, H., 1984, A fps gene without gag gene sequences transforms cells in culture and induces tumors in chickens, J. Virol., 48: 744.
Foster, D.A., Shibuya, M., and Hanafusa, H., 1985, Activation of the transformation potential of the cellular fps gene, Cell, 42: 105.
Golden, A., Nemeth, S.P., and Brugge, J.S., 1986, Blood platelets express high levels of the p60c-src-specific tyrosine kinase activity, Proc. Natl. Acad. Sci. USA, 83: 852.
Greer, P., Meckling-Hansen, K., and Pawson, T., 1988, Human c-fps/fes gene product expressed ectopically in rat fibroblasts is non-transforming and has restrained protein-tyrosine kinase activity, Mol. Cell. Biol., In Press.
Groffen, J., Reisterkamp, N., Shibuya, M., Hanafusa, H., and Stephenson, J.F., 1983, Transforming genes of avian (v-fps) and mammalian (vfes) retroviruses correspond to a common cellular locus, Virology, 125: 480.
Henderson, L.E., Krutzsch, H.C., and Oroszlan, S., 1983, Myristyl amino-terminal acylation of murine retrovirus proteins: An unusual post-translational protein modification, Proc. Natl. Acad. Sci. USA, 80: 339.
Hunter, T., and Cooper, J.A., 1985, Protein-tyrosine kinases, Annu. Rev. Biochem., 54: 897.
Kamps, M.P., Taylor, S.S., and Sefton, B.M., 1984, Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinases have homologous ATP-binding sites, Nature, 310: 589.
MacDonald, I., Levy, J., and Pawson, T., 1985, Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein, Mol. Cell. Biol., 5: 2543.
Mathey-Prerot, B., Hanafusa, H., andKawai, S., 1982, A cellular protein is immunologically cross-reactive with and functionally homologous to the Fujinami sarcoma virus transforming protein, Cell, 28: 897.
Meckling-Hansen, K., Nelson, R., Branton, P., and Pawson, T., 1987, Enzymatic activation of Fujinami sarcoma virus gag-fps transforming proteins by autophosphorylation at tyrosine, EMBO J., 6: 659.
Patschinsky, T., Hunter, T., Esch, F., Cooper, J., and Sefton, B., 1982
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation, Proc. Natl. Acad. Sci. USA, 79: 973.
Pawson, T., Guyden, J., Kung, T.-H., Radke, K., Gilmore, T., and Martin, G.S., 1980, A strain of Fujinami sarcoma virus which istemperature-sensitive in protein phosphorylation and cellular transformation, Cell, 22: 767.
Pellman, D., Garber, E.A., Cross F.R., and Hanafusa, H., 1985, An N-terminal peptide from p60stc can direct myristylation and plasma membrane localization when fused to heterologous proteins, Nature, 314: 374.
Rohrschneider, L.R., and Gentry, L.E., 1984, Subcellular location of retroviral transforming proteins define multiple mechanisms of transformation, Adv. Virol. Oncol., 4: 269.
Sadowski, I., and Pawson, T., 1987, Catalyati€ and non-catalytic domains of the Fujinami sarcoma virus P138g g- Ps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli, Oncogene, 1: 181.
Sadowski, I., Stone, J.C., and Pawson, T., 1986, A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-ps, Mol. Cell. Biol., 6: 4396.
Samarut, J., Mathey-Prevot, B., and Hanafusa, H., 1985, Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells, Mol. Cell. Biol., 5: 1067.
Shibuya, M., and Hanafusa, H., 1982, Nucleotide sequence of Fujinam sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses, Cell, 30: 787.
Stone, J.C., Atkinson, T., Smith, M., and Pawson, T., Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis, 1984, Cell, 37: 549.
Stone, J.C., and Pawson, T., 1985, Correspondence between immunological and functional domains in the transforming protein of Fujinami sarcoma virus, J. Virol., 55: 721.
Weinmaster, G., Hinze, E., and Pawson, T., 1983, Mapping of multiple phosphorylation sites within structural and catalytic domains of the Fujinami avian sarcoma virus transforming protein, J. Virol., 46: 29.
Weinmaster, G., and Pawson, T., Protein kinase activity of FSV P130gag shows a strict specificity for tyrosine residues, J. Biol. Chem., 261: 328.
Weinmaster, G., Zoller, M.J., Smith, M., Hinze, E., and Pawson, T., 1984, Mutagenesis of Fujinami sarcoma virus: Evidence that tyrosine phosphorylation of P130gag- Ps modulates its biological activity, Cell, 37: 559.
Weinmaster, G., Zoller, M.J., and Pawson, T., 1986, A lysine in the ATP- binding site of P130gag-fps is essential for protein-tyrosine kinase activity, EMBO, 5: 69.
Woolford, J., and Beemon, K., 1984, Transforming proteins of Fujinami and PRCII avian sarcoma viruses have different subcellular locations, Virology, 135: 168.
Young, J.C., and Martin, G.S., 1984, Cellular localization of c-fps gene product NCP98, J. Virol., 52: 913.
Zoller, M.J., and Taylor, S.S., 1979, Affinity labeling of the nucleotide binding site of the catalytic 1ubunit of cAMP-dependent protein kinase using p-fluorosulfonyl-[C] benzoyl-5’-adenosine, J. Biol. Chem., 17: 8368.
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Pawson, T., Greer, P., Moran, M., Meckling-Hansen, K., Brooks-Wilson, A., Sadowski, I. (1988). Structure-Function Relationships in Cellular and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. In: Kudlow, J.E., MacLennan, D.H., Bernstein, A., Gotlieb, A.I. (eds) Biology of Growth Factors. Advances in Experimental Medicine and Biology, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1980-2_5
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DOI: https://doi.org/10.1007/978-1-4757-1980-2_5
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