Chemical and Biochemical Properties of Human Angiogenin

  • Bert L. Vallee
  • James F. Riordan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 234)


It is now widely appreciated that neovascularization is essential for the growth and progression of solid tumors. Indeed, this requirement has led to the concept of tumor-induced angiogenesis whereby tumor cells secrete a substance or substances that promote the proliferation of neighboring blood vessels. Such a substance was, in fact, thought to be not only obligatory but also specific and peculiar to malignant cells. As a consequence, a great deal of attention has been directed toward the isolation and characterization of such a material. Containment of neoplastic growth through specific control of the tumor-induced angiogenic process has been suggested to be a potential therapeutic approach and this has added additional impetus to the effort.


Rabbit Reticulocyte Lysate Pancreatic Ribonuclease Tumor Conditioned Medium Ribonucleolytic Activity Bovine Pancreatic Ribonuclease 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Bert L. Vallee
    • 1
  • James F. Riordan
    • 1
  1. 1.Center for Biochemical and Biophysical Sciences and MedicineHarvard Medical SchoolBostonUSA

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