Molecular and Developmental Biology Aspects of Fibroblast Growth Factor

  • Denis Gospodarowicz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 234)


Basic and acidic fibroblast growth factors (FGFs) are two closely related peptides of Mr =16000 that act as potent mitogens and differentiation factors or a wide variety of mesoderm and neuroectoderm derived cells. Basic FGF (bFGF pI 9.6) was first identified by its ability to cause the proliferation and phenotypic transformation of BALB-C 3T3 fibroblasts (Gospodarowicz,1974;Gospodarowicz and Moran,1974), while acidic FGF (aFGF, pI 5.6) was first identified by its ability to cause the proliferation and delayed differentiation of myoblasts (Gospodarowicz et al.,1975). It was later rediscovered on the basis of its ability to stimulate endothelial cell proliferation (Lemmon et al.,1982; Maciag et al.,1978).


Fibroblast Growth Factor Granulosa Cell Fibroblast Growth Factor Receptor Basic Fibroblast Growth Factor Endothelial Cell Proliferation 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Denis Gospodarowicz
    • 1
  1. 1.Cancer Research InstituteUniversity of California Medical CenterSan FranciscoUSA

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