Skip to main content
SpringerLink
Log in

Platelet-Derived Growth Factor — Its Role in Health and Disease

  • Chapter
Biology of Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 234))

Abstract

It has been well known for many years that serum is required for the growth of most diploid cells in culture. Several attempts were made to determine the source of the growth activity present in serum. Partially purified fractions that contained mitogenic activity were isolated, but none of these demonstrated the cellular source of this proliferative activity. In 1974, it was observed that platelets were the source of the principal mitogenic activity present in whole blood serum and absent in cell-free plasma-derived serum.1,2 These observations were made initially for smooth muscle cellsl and subsequently for mouse embryo 3T3 cells.2 At that time it was not clear whether there was more than one growth factor present in platelets. However, the major mitogen released by platelets, which is the subject of this report, has been termed the platelet-derived growth factor (PDGF).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R. Ross, J. A. Glomset, B. Kariya, and L. Harker. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Acad. Sci. USA 71: 1207 (1974).

    Article  PubMed  CAS  Google Scholar 

  2. N. Kohler and A. Lipton. Platelets as a source of fibroblast growth-promoting activity. Exp. Cell Res. 87: 297 (1974).

    Article  PubMed  CAS  Google Scholar 

  3. Y. Oka and D. N. Orth. Human plasma epidermal growth factor/8-urogastrone is associated with blood platelets. J. Clin. Invest. 72: 249 (1983).

    Article  PubMed  CAS  Google Scholar 

  4. R. K. Assoian, A. Komoriya, C.A. Meyers, D. M. Miller and M. B. Sporn. Transforming growth factor-beta in human platelets. J. Biol. Chem. 258: 7155 (1983).

    PubMed  CAS  Google Scholar 

  5. G. L. King and S. Buchwald. Characterization and partial purification of an endothelial cell growth factor from human platelets. J. Clin. Invest. 73:392 (1984).

    Google Scholar 

  6. K. Miyazono, T. Okabe, A. Urabe, T. Fumimaro and C. -H. Heldin. Purification and properties of an endothelial cell growth factor from human platelets. J. Biol. Chem. 262: 4098 (1987).

    PubMed  CAS  Google Scholar 

  7. D. F. Bowen-Pope, R. A. Seifert and R. Ross. The platelet-derived growth factor receptor, in: “Control of Animal Cell Proliferation,” A. L. Boynton and H. L. Leffert, eds., Academic Press, New York, p. 281 (1985).

    Google Scholar 

  8. E. W. Raines and R. Ross. Platelet-derived growth factor. I. High yield purification and evidence for multiple forms. J. Biol. Chem. 257: 5154 (1982).

    CAS  Google Scholar 

  9. C. -H. Heldin, B. Westermark and A. Wasteson. Platelet-derived growth factor: isolation by a large-scale procedure and anlysis of subunit composition. Biochem. J. 193: 907 (1981).

    CAS  Google Scholar 

  10. H. N. Antoniades. Human platelet-derived growth factor (PDGF): purification of PDGF-I and PDGF-II and separation of their reduced subunits. Proc. Natl. Acad. Sci. USA 78: 7314 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. T. F. Deuel and J. S. Huang. Platelet-derived growth factor: purification, properties, and biological activities. Prog. Hematol. 13:201 (1983)

    Google Scholar 

  12. A. Johnsson, C. -H. Heldin, A. Wasteson, B. Westermark, T. F. Deuel, J. S. Huang, P. H. Seeburg, A. Gray, A. Ullrich, G. Scrace, P. Stroobant and M. D. Waterfield. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J. 3: 921 (1984).

    PubMed  CAS  Google Scholar 

  13. P. Stroobant and M. D. Waterfield. Purification and properties of porcine platelet-derived growth factor. EMBO J. 3: 2963 (1984).

    PubMed  CAS  Google Scholar 

  14. C. -H. Heldin, A. Johnsson, S. Wennergren, C. Wernstadt, C. Betsholtz and B. Westermark. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature 319: 511 (1986).

    CAS  Google Scholar 

  15. R. F. Doolittle, M. W. Hunkapiller, L. E. Hood, S. G. Devare, K. C. Robbins, S. A. Aaronson and H. N. Antoniades. Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221: 275 (1983).

    CAS  Google Scholar 

  16. M. D. Waterfield, G. T. Scrace, N. Whittle, P. Stroobant, A. Johnsson, A. Wasteson, B. Westermark, C. -H. Heldin, J. S. Huang and T. F. Deuel. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 304: 35 (1983).

    CAS  Google Scholar 

  17. K. C. Robbins, H. N. Antoniades, S. G. Devare, M. W. Hunkapiller and S. A. Aaronson. Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor. Nature 305: 605 (1983).

    CAS  Google Scholar 

  18. A. Johnsson, C. Betsholtz, K. von der Helm, C. -H. Heldin and B. Westermark. Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product. Proc. Natl. Acad. Sci. USA 82:1721 (1985).

    Google Scholar 

  19. J. D. Kelly, E. W. Raines, R. Ross and M. J. Murray. The B chain of PDGF alone is sufficient for mitogenesis. EMBO J. 4: 3399 (1985).

    PubMed  CAS  Google Scholar 

  20. C. Betsholtz, A. Johnsson, C. -H. Heldin, B. Westermark, P. Lind, M. S. Urdea, R. Eddy, T. B. Shows, K. Philpott, A. L. Mellor, T. J. Knott and J. Scott. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320: 695 (1986).

    Article  PubMed  CAS  Google Scholar 

  21. T. F. Deuel and J. S. Huang. Roles of growth factor activities in oncogenesis. Blood 64: 951 (1984).

    CAS  Google Scholar 

  22. R. Ross, E. W. Raines and D. F. Bowen-Pope. The biology of platelet-derived growth factor. Cell 46: 155 (1986).

    Article  PubMed  CAS  Google Scholar 

  23. C. D. Stiles. The molecular biology of platelet-derived growth factor. Cell 33: 653 (1983).

    Article  PubMed  CAS  Google Scholar 

  24. C. -H. Heldin and B. Westermark. Growth factors: mechanism of action and relation to oncogenes. Cell 37: 9 (1984).

    Article  PubMed  CAS  Google Scholar 

  25. K. Glenn, D. Bowen-Pope and R. Ross. Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling. J. Biol. Chem. 257: 5172 (1982).

    PubMed  CAS  Google Scholar 

  26. C. E. Hart, R. A. Seifert, R. Ross and D. F. Bowen-Pope. Synthesis, phosphorylation and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody. J. Biol. Chem., in press.

    Google Scholar 

  27. L. J. Pike, D. Bowen-Pope, R. Ross and E. G. Krebs.

    Google Scholar 

  28. Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes. J. Biol. Chem. 258: 9383 (1983).

    Google Scholar 

  29. A. R. Frackelton Jr., P. M. Tremble and L. T. Williams. Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. J. Biol. Chem. 259: 7909 (1984).

    PubMed  CAS  Google Scholar 

  30. C. -H. Heldin, B. Ek and L. Ronnstrand. Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000 dalton substrate for the PDGF-stimulated kinase. J. Biol. Chem. 258: 10054 (1983).

    PubMed  CAS  Google Scholar 

  31. Y. Yarden, J. A. Escobedo, W. -J. Kuang, T. L. Yang-Feng, T. 0. Daniel, P. M. T.emble, E. Y. Chen, M. E. Ando, R. N. Harkins, U. Francke, V. A. Fried, A. Ullrich and L. T. Williams. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323: 226 (1986).

    Google Scholar 

  32. J. A. Cooper, D. F. Bowen-Pope, E. Raines, R. Ross and T. Hunter. Similar effects of platelet-derived growth factor and epidermal growth factor on phosphorylation of tyrosine in cellular proteins. Cell 31: 263 (1982).

    Article  PubMed  CAS  Google Scholar 

  33. D. F. Bowen-Pope, T. W. Malpass, D. M. Foster and R. Ross. Platelet-derived growth factor in vivo: levels, activity, and rate of clearance. Blood 64: 458 (1984).

    CAS  Google Scholar 

  34. E. B. Leof, J. A. Proper, A. S. Goustin, G. D. Shipley, P. E. DiCorleto and H. L. Moses. Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth

    Google Scholar 

  35. factor 8: a proposed model for indirect mitogenesis involving autocrine activity. Proc. Natl. Acad. Sci. USA 83:2453 (1986).

    Google Scholar 

  36. T. B. Barrett, C. M. Gajdusek, S. M. Schwartz, J. K. McDougall and E. P. Benditt. Expression of the sis gene by endothelial cells in culture and in vivo. Proc. Natl. Acad. Sci. USA 81:6772 (1984).

    Google Scholar 

  37. T. Papayannopoulou, E. Raines, S. Collins, B. Nakamoto, M. Tweeddale and R. Ross. Constitutive and inducible secretion of platelet-derived growth factor analogs by human leukemic cell lines coexpressing erythroid and megakaryocytic markers. J. Clin. Invest. 79:859 (1987).

    Google Scholar 

  38. J. M. Harlan, P. J. Thompson, R. Ross and D. F. Bowen-Pope. a-thrombin induces release of PDGF-like molecule(s) by cultured human endothelial cells. J. Cell Biol. 103: 1129 (1986).

    Article  PubMed  CAS  Google Scholar 

  39. J. C. Smith, J. P. Singh, J. S. Lillquist, D. S. Goon and C. D. Stiles. Growth factors adherent to cell substrate are mitogenically active in situ. Nature 296: 154 (1982).

    CAS  Google Scholar 

  40. Y. Shing, J. Folkman, R. Sullivan, C. Butterfield, J. Murray and M. Klagsbrun. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 223: 1296 (1984).

    CAS  Google Scholar 

  41. E. W. Raines, D. F. Bowen-Pope and R. Ross. Plasma binding proteins for platelet-derived growth factor that inhibit its binding to cell-surface receptors. Proc. Natl. Acad. Sci. USA 81:3424 (1984).

    Google Scholar 

  42. J. S. Huang, S. S. Huang and T. F. Deuel. Specific covalent binding of platelet-derived growth factor to human plasma alpha-2- macroglobulin. Proc. Natl. Acad. Sci. USA 81:342 (1984)

    Google Scholar 

  43. A. J. R. Habenicht, J. A. Glomset, W. C. King, C. Nist, C. D. Mitchell and R. Ross. Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent Swiss 3T3 cells stimulated to divide by platelet-derived growth factor. J. Biol. Chem.256:12329 (1981).

    Google Scholar 

  44. W. T. Shier. Serum stimulation of phospholipase A2 and prostaglandin release in 3T3 cells is associated with platelet-derived growth-promoting activity. Proc. Natl. Acad. Sci. USA 77: 137 (1980).

    Article  CAS  Google Scholar 

  45. A. H. Tashjian Jr., E. F. Voelkel, M. Lazzaro, F. R. Singer, A. B. Roberts, R. Derynck, M. E. Winkler and L. Levine. a and 8 human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc. Natl. Acad. Sci. USA 82: 4535 (1985).

    Article  CAS  Google Scholar 

  46. S. Moncada and J. R. Vane. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N. Engl. J. Med. 300: 1142 (1979).

    CAS  Google Scholar 

  47. B. Samuelsson, M. Goldyne, E. Granstrom, M. Hamberg, S. Hammarstrom, and C. Malmsten. Prostaglandins and thromboxanes. Ann. Rev. Biochem. 47: 997 (1978).

    Article  CAS  Google Scholar 

  48. A. J. R. Habenicht, M. Goerig, J. Grulich, D. Rothe, R. Gronwald, U. Loth, G. Schettler, B. Kommerell and R. Ross. Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase. J. Clin. Invest. 75: 1381 (1985).

    Article  PubMed  CAS  Google Scholar 

  49. A. J. R. Habenicht, H. A. Dresel, M. Goerig, J. -A. Weber, M. Stoehr, J. A. Glomset, R. Ross and G. Schettler. Low-density lipoprotein receptor-dependent prostaglandin synthesis in Swiss 3T3 cells stimulated by platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 83: 1344 (1986).

    Article  PubMed  CAS  Google Scholar 

  50. A. Chait, R. Ross, J. J. Albers and E. L. Bierman. Platelet-derived growth factor stimulates activity of low density lipoprotein receptors. Proc. Natl. Acad. Sci. USA 77:4084 (1980).

    Google Scholar 

  51. L. D. Witte, J. A. Cornicelli, R. W. Miller and D. S. Goodman. Effects of platelet-derived and endothelial cell-derived growth factors on the low density lipoprotein receptor pathway in cultured human fibroblasts. J. Biol. Chem. 257:5392 (1982).

    Google Scholar 

  52. S. A. Narayanan and R. C. Page. Biosynthesis and regulation of type V collagen in diploid human fibroblasts. J. Biol. Chem. 258: 11694 (1983).

    PubMed  CAS  Google Scholar 

  53. C. C. Chua, D. E. Geiman, G. H. Keller and R. L. Ladda. Induction of collagenase secretion in human fibroblast cultures by growth promoting factors. J. Biol. Chem. 260: 5213 (1985).

    PubMed  CAS  Google Scholar 

  54. E. A. Bauer, T. W. Cooper, J. S. Huang, J. Altman and T. F. Deuel. Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 82: 4132 (1985).

    Article  PubMed  CAS  Google Scholar 

  55. G. R. Grotendorst, T. Chang, H. E. J. Seppa, H. K. Kleinman and G. R. Martin. Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J. Cell. Physiol. 113:261 (1982)’.

    Google Scholar 

  56. H. Seppa, G. Grotendorst, S. Seppa, E. Schiffmann and G. R. Martin. Platelet-derived growth factor is chemotactic for fibroblasts. J. Cell Biol. 92: 584 (1982).

    Article  PubMed  CAS  Google Scholar 

  57. T. F. Deuel, R. M. Senior, J. S. Huang and G. L. Griffin. Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J. Clin. Invest. 69:1046 (1982).

    Google Scholar 

  58. L. T. Williams, H. N. Antoniades and E. J. Goetzl. Platelet-derived growth factor stimulates mouse 3T3 cell mitogenesis and leukocyte chemotaxis through different structural determinants. J. Clin. Invest. 72: 1759 (1983).

    Article  PubMed  CAS  Google Scholar 

  59. D. Y. Tzeng, T. F. Deuel, J. S. Huang, R. M. Senior, L. A. Boxer and R. L. Baehner . Platelet-derived growth factor promotes polymorphonuclear leukocyte activation. Blood 64: 1123 (1984).

    PubMed  CAS  Google Scholar 

  60. R. B. Acres, J. R. Lam and M. Feldman. Effects of platelet-derived growth factor and epidermal growth factor on antigen-induced proliferation of human T-cell lines. Immunology 54: 9 (1985).

    PubMed  CAS  Google Scholar 

  61. N. Dainiak, G. Davies, M. Kalmanti, J. Lawler and V. Kulkarni. Platelet-derived growth factor promotes the proliferation of erythropoietic progenitor cells in vitro. J. Clin. Invest. 71: 1206 (1983).

    Google Scholar 

  62. F. Delwiche, E. Raines, J. Powell, R. Ross and J. Adamson. Platelet-derived growth factor enhances in vitro erythropoiesis via stimulation of mesenchymal cells. J. Clin. Invest. 76: 137 (1985).

    Article  PubMed  CAS  Google Scholar 

  63. D. R. Clemmons and J. J. Van Wyk. Evidence for a functional role of endogenously produced somatomedin-like peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells. J. Clin. Invest. 75:1914, 1985.

    Google Scholar 

  64. B. C. Berk, R. W. Alexander, T. A. Brock, M. A. Gimbrone and C. R. Webb. Vasoconstriction: a new activity for platelet-derived growth factor. Science 232: 87 (1986).

    Article  PubMed  CAS  Google Scholar 

  65. L. D. Witte, K. L. Kaplan, H. L. Nossel, B. A. Lages, H. J. Weiss and D. S. Goodman. Studies of the release from human platelets of the growth factor for cultured human arterial smooth muscle cells. Circ. Res. 42: 402 (1978).

    Article  PubMed  CAS  Google Scholar 

  66. D. R. Kaplan, M. J. Broekman, A. Chernoff, G. R. Lesznik and M. Drillings. Platelet alpha-granule proteins: studies on release and subcellular localization. Blood 53: 604 (1979).

    PubMed  CAS  Google Scholar 

  67. J. M. Gerrard, D. R. Phillips, G. H. R. Rao, E. F. Plow, D. A. Walz, R. Ross, L. A. Harker and J. G. White. Biochemical studies of two patients with the gray platelet syndrome. J. Clin. Invest. 66: 102 (1980).

    Google Scholar 

  68. C. -H. Heldin, B. Westermark and A. Wasteson. Demonstration of an antibody against platelet-derived growth factor. Exp. Cell Res. 136: 255 (1981).

    Article  PubMed  CAS  Google Scholar 

  69. S. J. Leibovich and R. Ross. A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro. Am. J. Pathol. 84: 501 (1976).

    PubMed  CAS  Google Scholar 

  70. K. Glenn and R. Ross. Human monocyte-derived growth factor(s) for mesenchymal cells: activation of secretion by endotoxin and concanavalin A. Cell 25: 603 (1981).

    Article  PubMed  CAS  Google Scholar 

  71. K. Shimokado, E. W. Raines, D. K. Madtes, T. B. Barrett, E. P. Benditt and R. Ross. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 43: 277 (1985).

    Article  PubMed  CAS  Google Scholar 

  72. Y. Martinet, P. B. Bitterman, J. -F. Mornex, G. R. Grotendorst, G. R. Martin and R. G. Crystal. Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity. Nature 319: 158 (1986).

    CAS  Google Scholar 

  73. J. -F. Mornex, Y. Martinet, K. Yamauchi, P. B. Bitterman, G. R. Grotendorst, A. Chytil-Weir, G. R. Martin and R. G. Crystal. Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages. J. Clin. Invest. 78: 61 (1986).

    Article  PubMed  CAS  Google Scholar 

  74. B. M. Martin, M. A. Gimbrone Jr., E. R. Unanue and R. S. Cotran. Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor. J. Immunol. 126: 1510 (1981).

    PubMed  CAS  Google Scholar 

  75. P. E. DiCorleto and D. F. Bowen-Pope. Cultured endothelial cells produce a platelet-derived growth factor-like protein. Proc. Natl. Acad. Sci. USA 80:1919 (1983).

    Google Scholar 

  76. P. E. DiCorleto. Cultured endothelial cells produce multiple growth factors for connective tissue cells. Exp. Cell Res. 153: 167 (1984).

    Article  Google Scholar 

  77. T. B. Barrett, C. M. Gajdusek, S. M. Schwartz, J. K. McDougall and E. P. Benditt. Expression of the sis gene by endothelial cells in culture and in vivo. Proc. Natl. Acad. Sci. USA 81:6772 (1984).

    Google Scholar 

  78. T. Collins, D. Ginsburg, J. M. Boss, S. H. Orkin and J. S. Pober. Cultured human endothelial cell express platelet-derived growth factor chain 2: cDNA cloning and structural analysis. Nature 316: 748 (1985).

    Google Scholar 

  79. C. Gajdusek, S. Carbon, R. Ross, P. Nawroth and D. Stern. Activation of coagulation releases endothelial cell mitogens. J. Cell Biol. 103: 419 (1986).

    Article  PubMed  CAS  Google Scholar 

  80. R. A. Seifert, S. M. Schwartz and D. F. Bowen-Pope. Developmentally regulated production of platelet-derived growth factor-like molecules. Nature 311: 669 (1984).

    CAS  Google Scholar 

  81. L. N. Walker, D. F. Bowen-Pope, R. R.ss and M. A. Reidy. Production of PDGF-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. Proc. Natl. Acad. Sci. USA 83: 7311 (1986).

    Article  PubMed  CAS  Google Scholar 

  82. D. F. Bowen-Pope, A. Vogel and R. Ross. Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents. Proc. Natl. Acad. Sci. USA 81:2396 (1984).

    Google Scholar 

  83. J. S. Huang, S. S. Huang and T. F. Deuel. Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors. Cell 39: 79 (1984).

    Article  PubMed  CAS  Google Scholar 

  84. A. S. Goustin, C. Betsholtz, S. Pfeifer-Ohlsson, H. Persson, J. Rydnert, M. Bywater, G. Holmgren, C. -H. Heldin, B. Weatermark and R. Ohlsson. Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell 41: 301 (1985).

    Article  PubMed  CAS  Google Scholar 

  85. A. Faggiotto, R. Ross and L. Harker. Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Arteriosclerosis 4: 323 (1984).

    Article  PubMed  CAS  Google Scholar 

  86. R. Ross. The pathogenesis of atherosclerosis: an update. N. Engl. J. Med. 314: 488 (1986).

    Article  PubMed  CAS  Google Scholar 

  87. R. G. Gerrity. The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am. J. Pathol. 103: 181 (1981).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Washington, Seattle, WA, USA

    Russell Ross & Elaine W. Raines

Authors
  1. Russell Ross
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elaine W. Raines
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Ontario, Canada

    Jeffrey E. Kudlow

  2. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    David H. MacLennan

  3. Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

    Alan Bernstein

  4. Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Ontario, Canada

    Avrum I. Gotlieb

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ross, R., Raines, E.W. (1988). Platelet-Derived Growth Factor — Its Role in Health and Disease. In: Kudlow, J.E., MacLennan, D.H., Bernstein, A., Gotlieb, A.I. (eds) Biology of Growth Factors. Advances in Experimental Medicine and Biology, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1980-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1980-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1982-6

  • Online ISBN: 978-1-4757-1980-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation