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The Endosomal Apparatus and Transmembrane Signalling

  • Chapter
Biology of Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 234))

Abstract

The binding of insulin, prolactin, and epidermal growth factor to their respective receptors on liver parenchymal cells rapidly leads to their internalization along with their associated receptors. As reviewed elsewhere, 1–5 high concentrations of these ligand-receptor complexes accumulate initially in a heterogeneous group of compartments collectively termed the endosomal apparatus. Conceptually, the endosomal apparatus bridges the plasmalemma with secondary lysosomes and involves at least indirectly the Golgi apparatus (Fig. 1 and 14–17). In liver, components of the endosomal apparatus have been visualized and identified by electron microscope radioautography, 18 EM immunocytochemistry, 19–23 and subcellular fractionation 7–11,24. These techniques have demonstrated that the endosomal components are not lysosomes, 10,12,18,25 that a sequential transport of ligands and receptors among endosomal components can be observed, 8,9,26,29 and that morphologically different microdomains can be observed in continuous structures segregating ligands (vesicular) from receptors (tubular)19–21.

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Authors and Affiliations

  1. McGill University, Montreal, Quebec, H3A 2B2, Canada

    J. J. M. Bergeron, W. H. Lai, D. G. Kay, J. J. Doherty II, M. N. Khan & B. I. Posner

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  1. J. J. M. Bergeron
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  2. W. H. Lai
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  3. D. G. Kay
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  4. J. J. Doherty II
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  5. M. N. Khan
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  6. B. I. Posner
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Editors and Affiliations

  1. Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Ontario, Canada

    Jeffrey E. Kudlow

  2. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    David H. MacLennan

  3. Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

    Alan Bernstein

  4. Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Ontario, Canada

    Avrum I. Gotlieb

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Bergeron, J.J.M., Lai, W.H., Kay, D.G., Doherty, J.J., Khan, M.N., Posner, B.I. (1988). The Endosomal Apparatus and Transmembrane Signalling. In: Kudlow, J.E., MacLennan, D.H., Bernstein, A., Gotlieb, A.I. (eds) Biology of Growth Factors. Advances in Experimental Medicine and Biology, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1980-2_14

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