Function of the Antigen Receptor in T Cell Activation

  • Mark A. Goldsmith
  • Arthur Weiss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 234)


The T lymphocyte plays a central role in both regulatory and effector aspects of the immune response to foreign antigens. In its regulatory role, represented for example by the T helper cell, the T lymphocyte is involved in complex interactions with antigen presenting cells, B cells, and other T cells. Communication in these interactions rely on both cell-to-cell contacts as well as the release of soluble growth and differentiation factors (lymphokines and monokines). In its effector role, represented by the cytotoxic T cell, direct engagement of infected cells results in destruction of the target.


Jurkat Cell Antigen Receptor Chloramphenicol Acetyl Transferase Transmembrane Signalling Cell Antigen Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Mark A. Goldsmith
    • 1
  • Arthur Weiss
    • 1
  1. 1.Howard Hughes Medical Institute, Departments of Medicine and of Microbiology and ImmunologyUniversity of California, San FranciscoSan FranciscoUSA

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