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Biology of Growth Factors pp 195–211Cite as

Function of the Antigen Receptor in T Cell Activation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 234))

Abstract

The T lymphocyte plays a central role in both regulatory and effector aspects of the immune response to foreign antigens. In its regulatory role, represented for example by the T helper cell, the T lymphocyte is involved in complex interactions with antigen presenting cells, B cells, and other T cells. Communication in these interactions rely on both cell-to-cell contacts as well as the release of soluble growth and differentiation factors (lymphokines and monokines). In its effector role, represented by the cytotoxic T cell, direct engagement of infected cells results in destruction of the target.

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Departments of Medicine and of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94143, USA

    Mark A. Goldsmith & Arthur Weiss

Authors
  1. Mark A. Goldsmith
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  2. Arthur Weiss
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Editor information

Editors and Affiliations

  1. Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Ontario, Canada

    Jeffrey E. Kudlow

  2. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    David H. MacLennan

  3. Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

    Alan Bernstein

  4. Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Ontario, Canada

    Avrum I. Gotlieb

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© 1988 Springer Science+Business Media New York

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Goldsmith, M.A., Weiss, A. (1988). Function of the Antigen Receptor in T Cell Activation. In: Kudlow, J.E., MacLennan, D.H., Bernstein, A., Gotlieb, A.I. (eds) Biology of Growth Factors. Advances in Experimental Medicine and Biology, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1980-2_13

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  • DOI: https://doi.org/10.1007/978-1-4757-1980-2_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1982-6

  • Online ISBN: 978-1-4757-1980-2

  • eBook Packages: Springer Book Archive

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