The ras Pathway: A Model for the Control of Proliferation in Animal Cells
Scrupulous control over cellular proliferation is essential for the survival of a multicellular organism, yet little is known about the mechanism of this control. A variety of factors are known to influence cell division in both positive and negative ways. These include diffusible factors and the results of cell-cell contact. While the ultimate decision concerning cell division is most likely made at the molecular level within a specific cell, this decision must be based upon the signals received from outside the cell. In this study data and hypotheses are presented primarily regarding the means by which extracellular proliferative signals are transferred into the cell. This discussion, therefore, represents an important but limited aspect of the control of proliferation within the organism. While the discussion will center primarily upon a presentation of data, hypotheses relating to these data will also be included. In many cases, the hypotheses are only speculative at present.
KeywordsPhosphatidic Acid Thymidine Incorporation Mitogenic Stimulation Thymidine Labelling Cellular Oncogene
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- Barbacid, M., 1987, ras genes, Annual. Rev. Biochem., (in press).Google Scholar
- Deshpande, A.K., and Kung, H.-F., 1987, Insulin induction of Xenopus Bevis oocyte maturation is inhibited by monoclonal antibody against p2lras proteins, Mol. Cell. Biol., 3: 1285–1288.Google Scholar
- Lacal, J.G., Santos, E., Notario, V., Barbacid, M., Yamazaki, S., Kung, H.-F., Seamans, C., McAndrew, S., and Crowl,R., 1984, Expression of normal and transforming H-ras genes in Escherichla Coil and purification of their encoded p21 proteins, Proc. Natl. Acad. Scia USA, 81: 5305–5309.CrossRefGoogle Scholar
- Stacey, D.W., DeGudicibus, S.R.., and Smith, M.R., 1987, Cellular ras activity and tumor cell proliferation, Exptl. Cell Res., (in press).Google Scholar
- Yu, C.-L., Tsai, M.-W., and Stacey, D.W., Cellular ras activity and phospholipid metabolism, (in review).Google Scholar