Functional, Morphological, and Microbiological Effects of Piezoelectric Shock Wave Lithotripsy (EDAP LT01): An Experimental and Clinical Study
The biological effects of the EDAP LT01 lithotripter were examined in 20 rabbits subjected to piezoelectric shock wave lithotripsy (PSWL). No functional or morphologic abnormalities were noted with standard dose PSWL (6,000 shock waves). Although renal contusions were demonstrable 24 hours following excess dose PSWL (24,000 shock waves), no acute changes were found in renal function (as measured by 99mTc mercaptoacetyltriglycine isotope scans). No functional or morphologic abnormalities were observed in animals examined 30 days following excess dose PSWL.
The effects of PSWL were also examined in 26 patients receiving 6,000 shock waves. No adverse effects were noted clinically other than transient hematuria. There were no alterations in renal function.
PSWL using 6,000 shock waves does not affect renal morphology or function and is well tolerated clinically.
KeywordsShock Wave Shock Wave Lithotripsy Extracorporeal Shock Wave Lithotripsy Acute Pyelonephritis Excess Dose
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