Changes in Rabbit Renal Physiology Following Extracorporeal Shock Wave Treatment
Both renal units of nine New Zealand white rabbits were subjected to extracorporeal shock waves in a Dornier experimental lithotripter. Each kidney received 3,000 shock waves at 18 kV. Twenty-four hour creatinine clearances were then determined for all nine rabbits on a daily basis for the first seven days following shock wave treatment (short-term study). Three rabbits were then followed on a weekly basis for two months following shock wave treatment (long-term study). A significant reduction in creatinine clearance occurred from a pre-treatment level of 8.3 ml/min to 0.61 ml/min on Day 1, 0.87 ml/min on Day 2, and 1.04 ml on Day 3. Creatinine clearance returned to control values by Day 5 in the short-term study and by Day 14 in the long-term study. This study demonstrates that extracorporeal shock waves at clinical levels do result in short-term reduction in renal function in rabbits; however, this effect appears to be reversible. We also believe that this technique presents an animal model that can be used for investigation of effects of shock waves on renal physiology.
KeywordsShock Wave Creatinine Clearance Shock Wave Lithotripsy Extracorporeal Shock Wave Lithotripsy Zealand White Rabbit
Unable to display preview. Download preview PDF.
- 1.Riehle RA: Principles of Extracorporeal Shock Wave Lithotripsy. New York: Churchill Livingstone, 1987.Google Scholar
- 2.Chaussy C, Schmiedt E, Jocham D, et al: Extracorporeal Shock Wave Lithotripsy: New Aspects in the Treatment of Kidney Stone Diseases. Basel, Switzerland: Karger, 1982.Google Scholar