Direct Effects of Shock Waves on Human Prostate Tissue

  • Ali H. Mardan
  • Stefan A. Loening

Abstract

Shock waves have recently been found to cause damage to Dunning rat prostatic cancer cells and also to cause a delay in tumor growth. We studied the effect of shock waves on human prostate tissue using the Dornier XL1 lithotripter. Ten specimens of prostate tissue were obtained from patients who underwent transurethral prostatectomy for benign prostatic hypertrophy. Areas affected by electrosurgery were removed from the specimens, which were divided into four groups: controls and samples to be treated with 400, 800, or 1,600 shock waves at 15 kV. Treatment samples were individually exposed to shock waves in the tub of the XL1; a control specimen was placed in the far corner, where it was not exposed to shock waves. Examination by hematoxylin and eosin (H & E) showed no obvious histological changes in treated specimens, but examination by transmission electron microscopy (TEM) revealed several dose-dependent changes in the cellular ultrastructure, including cytoplasmic vacuolarization and damage to mitochondrial membranes and nucleus.

Keywords

Shock Wave Prostate Tissue Shock Wave Lithotripsy Extracorporeal Shock Wave Lithotripsy Benign Prostatic Hypertrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Ali H. Mardan
    • 1
  • Stefan A. Loening
    • 1
  1. 1.Department of UrologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA

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