Direct Effects of Shock Waves on Human Prostate Tissue

  • Ali H. Mardan
  • Stefan A. Loening


Shock waves have recently been found to cause damage to Dunning rat prostatic cancer cells and also to cause a delay in tumor growth. We studied the effect of shock waves on human prostate tissue using the Dornier XL1 lithotripter. Ten specimens of prostate tissue were obtained from patients who underwent transurethral prostatectomy for benign prostatic hypertrophy. Areas affected by electrosurgery were removed from the specimens, which were divided into four groups: controls and samples to be treated with 400, 800, or 1,600 shock waves at 15 kV. Treatment samples were individually exposed to shock waves in the tub of the XL1; a control specimen was placed in the far corner, where it was not exposed to shock waves. Examination by hematoxylin and eosin (H & E) showed no obvious histological changes in treated specimens, but examination by transmission electron microscopy (TEM) revealed several dose-dependent changes in the cellular ultrastructure, including cytoplasmic vacuolarization and damage to mitochondrial membranes and nucleus.


Shock Wave Prostate Tissue Shock Wave Lithotripsy Extracorporeal Shock Wave Lithotripsy Benign Prostatic Hypertrophy 
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  1. 1.
    Chaussy C, Schmiedt E, Jocham D, et al: Extracorporeal shock wave lithotripsy (ESWL) for treatment of urolithiasis. J Urol 23: 59, 1984.CrossRefGoogle Scholar
  2. 2.
    Russo P, Stephenson R, Heston WDW, et al: The in vitro effect on high energy shock waves on human prostate cancer cell line PC-3. Proceedings of AACR 26: 267, 1985.Google Scholar
  3. 3.
    Russo P, Stephenson RA, Mies C, et al: High energy shock waves suppress tumor growth in vitro and in vivo. J Urol 135: 626, 1986.PubMedGoogle Scholar
  4. 4.
    Stephenson R, Russo P, Gay H, et al: The effects of extracorporeal shock waves on flow cytometric parameters in the Dunning R-3327AT-3 rat prostate tumor. J Urol 133: 371A (abstract), 1985.Google Scholar
  5. 5.
    Russo P, Mies C, Huryk R, et al: Histopathologic and ultrastructural correlations of tumor growth suppression by high energy shock waves. J Urol 137: 338, 1987.PubMedGoogle Scholar
  6. 6.
    Russo P, Heston WDW, Fair WR: Suppression of in vitro and in vivo tumor growth by high energy shock waves. Surg Forum 36: 646, 1985.Google Scholar
  7. 7.
    Lonn EE and Stumf PK: Electron transport and oxidative phosphorylation. In: Outlines of Biochemistry. New York: John Wiley and Sons, 1966.Google Scholar
  8. 8.
    Riehle RA and Newman RC (eds): Principles of Extracorporeal Shock WaveLithotripsy. The Physics and Geometry Pertinent to ESWL. New York: Churchill Livingstone, 1987.Google Scholar
  9. 9.
    Dormandy TL: Free radical reaction in biological system. Ann R Coll Surg Eng 62: 188, 1980.Google Scholar
  10. 10.
    Del Maestro RF, Thaw H, Bjork J, et al: Free radicals as mediators of tissue injury. Acta Physiol Scand 43: 492, 1980.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Ali H. Mardan
    • 1
  • Stefan A. Loening
    • 1
  1. 1.Department of UrologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA

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