Abstract
Chronic renal failure ranks as a leading cause of death among people with diabetes mellitus. Prior to clinical onset of diabetic nephropathy, the kidneys of people with diabetes undergo changes in both function and morphology. Functional changes include increases in glomerular filtration rate (GFR) [1] and urinary albumin excretion [2, 3]. The GFR increases by as as much as 20%–30%. Subsequently, intermittent protein excretion occurs and then increases. Ultimately the GFR decreases and end-stage renal disease occurs [4]. Renal failure develops more than 5 years after the onset of constant proteinuria in people with diabetes [5].
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Sepe, S.J., Teutsch, S.M. (1988). Epidemiology of Renal Involvement in Diabetes Mellitus. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Topics in Renal Medicine, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1974-1_3
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DOI: https://doi.org/10.1007/978-1-4757-1974-1_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1976-5
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