Abstract
Chronic renal failure ranks as a leading cause of death among people with diabetes mellitus. Prior to clinical onset of diabetic nephropathy, the kidneys of people with diabetes undergo changes in both function and morphology. Functional changes include increases in glomerular filtration rate (GFR) [1] and urinary albumin excretion [2, 3]. The GFR increases by as as much as 20%–30%. Subsequently, intermittent protein excretion occurs and then increases. Ultimately the GFR decreases and end-stage renal disease occurs [4]. Renal failure develops more than 5 years after the onset of constant proteinuria in people with diabetes [5].
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References
Mogensen CE: Kidney function and glomerular permeability to macromolecules in early juvenile diabetes. Scand J Clin Lab Invest 28: 79–90, 1971.
Mogensen CE: Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 310: 356–360, 1984.
Viberti GC, Hill RD, Jarrett, RJ, et al.: Microalbuminuria as a prediction of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1: 1430–1432, 1982.
Friedman EA: Diabetic renal disease. In: Ellenberg M, Rifkin H (eds) Diabetes mellitus: theory and practice, 3rd edn. New York: Medical Examination Publishing, 1983, pp 759–776.
Krolewski AS, Warram JH, Christlieb AR, et al.: The changing natural history of nephropathy in type I diabetes. Am J Med 78: 785–794, 1985.
Osterby R: Early phases in the development of diabetic glomerulopathy: a quantitative electron microscopic study. Acta Med Scand [Suppl 574] 197: 1–82, 1974.
Herman WH, Teutsch SM: Renal disorders associated with diabetes mellitus. In: Friedman EA, L’Esperance FA (eds) Diabetic renal—retinal syndrome, 3. Orlando FL: Grune and Stratton, 1986, pp 9–52.
Bjerkelund CJ: Diabetic renal disease: clinical studies of 1,335 diabetics treated in Med. Dept. A of the University Hospital, Oslo 1930–1950. Acta Med Scand 139: 133–145, 1951.
MacNeal PS, Rogers J: Symposium on diabetes and obesity: complications of diabetes mellitus. Med Clin North Am 39: 1607, 1955.
El Mahallawy MN, Sabour MS: Etiologic factors in diabetic nephropathy. JAMA 173: 1783–1788, 1960.
Marble A: The natural history of diabetes. Horm Metab Res [Suppl.] 4: 153–157, 1974.
West KM, Erdreich L, Stober JA: A detailed study of risk factors for retinopathy and nephropathy in diabetes. Diabetes 29: 501–508, 1980.
Andersen AR, Andersen JK, Christiansen JS, et al.: Prognosis for juvenile diabetes with nephropathy and failing renal function. Acta Med Scand 203: 131–134, 1978.
Waring GO: The sequelae of diabetes mellitus in midwestern American Indians. Diabetes 19: 403–404, 1970.
West KM: Diabetes in American Indians and other native populations of the new world. Diabetes 23: 841–855, 1974.
Eggers PW, Connerton P, McMullan M: The Medicare experience with end-stage renal disease. Health Care Financing Rev 5: 69–88, 1984.
Easterling RE: Racial factors in the incidence and causation of end-stage renal disease. Trans Am Soc Artif Intern Organs 23: 28–33, 1977.
Health Care Financing Administration, Bureau of Data Management and Strategy: Data from the Program Management and Medical Information Systems, 1979–1984, and census population estimates. Series P-25, no. 965.
Rettig BS, Teutsch SM: The incidence of end-stage renal disease in type I and type 11 diabetes mellitus. Diabetic Nephropathy 3: 26–27, 1984.
European Dialysis and Transplant Association (EDTA) Annual Report, 1983.
Entmacher PS, Root HF, Marks HH: Longevity of diabetic patients in recent years. Diabetes 13: 373–377, 1964.
Bell ET: Renal vascular disease in diabetes mellitus. Diabetes 2: 376–389, 1953.
Warren S, LeCompte PM, Legg MA: The pathology of diabetes mellitus, 4th edn. Philadelphia: Lea and Febiger, 1966, pp 512–513.
Goto Y, Sato SI, Masuda M: Causes of death in 3,151 diabetic autopsy cases. Tohoku J Exp Med 112: 339–353, 1974.
Balodimos MC: Diabetic nephropathy. In: Marble A, White P, Bradley RF, Krall LP (eds) Joslin’s diabetes mellitus 11th edn. Philadelphia: Lea and Febiger, 1978, pp 526–561.
Borch-Johnsen K, Andersen PK, Deckert T: The effect of proteinuria on relative mortality in type I (insulin-dependent) diabetes mellitus. Diabetologia 28: 590–596, 1985.
National Center for Health Statistics. US Department of Health and Human Services: Multiple cause of death data, Hyattsville, MD 1979.
Caird FJ: Survival of diabetics with proteinuria. Diabetes 10: 178–181, 1961.
Shapiro FL, Comty CM: Hemodialysis in diabetics: 1981 update. In: Friedman EA, L’Esperance FA (eds) Diabetic renal-retinal syndrome, 2. New York: Grune and Stratton, 1982, pp 65–72.
Kass EH: Pyelonephritis and bacteriuria: a major problem in preventive medicine. Ann Intern Med 56: 46–53, 1962.
Vejlsgaard R: Studies on urinary infection in diabetics. I. Bacteriuria in patients with diabetes mellitus and in control subjects. Acta Med Scand 179: 173–182, 1966.
Eknoyan G, Qunibi WY, Grissom RT, et al.: Renal papillary necrosis: an update. Medicine 61: 55–73, 1982.
D’Elia JA, Gleason RE, Alday M, et al.: Nephrotoxicity from angiographie contrast material. Am J Med 72: 719–725, 1982.
Weinrauch LA, Healy RW, Leland OS, et al.: Coronary angiography and acute renal failure in diabetic azotemic nephropathy. Ann Intern Med 86: 56–59, 1977.
Harkonen S, Kjellstrand CM: Exacerbation of diabetic renal failure following intravenous pyelography. Am J Med 63: 939–946, 1977.
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Sepe, S.J., Teutsch, S.M. (1988). Epidemiology of Renal Involvement in Diabetes Mellitus. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Topics in Renal Medicine, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1974-1_3
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DOI: https://doi.org/10.1007/978-1-4757-1974-1_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1976-5
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