Epidemiology of Renal Involvement in Diabetes Mellitus

  • Stephen J. Sepe
  • Steven M. Teutsch
Part of the Topics in Renal Medicine book series (TIRM, volume 6)


Chronic renal failure ranks as a leading cause of death among people with diabetes mellitus. Prior to clinical onset of diabetic nephropathy, the kidneys of people with diabetes undergo changes in both function and morphology. Functional changes include increases in glomerular filtration rate (GFR) [1] and urinary albumin excretion [2, 3]. The GFR increases by as as much as 20%–30%. Subsequently, intermittent protein excretion occurs and then increases. Ultimately the GFR decreases and end-stage renal disease occurs [4]. Renal failure develops more than 5 years after the onset of constant proteinuria in people with diabetes [5].


Diabetic Nephropathy Renal Involvement Diabetic Renal Disease Renal Papillary Necrosis Death Certificate Data 
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  1. 1.
    Mogensen CE: Kidney function and glomerular permeability to macromolecules in early juvenile diabetes. Scand J Clin Lab Invest 28: 79–90, 1971.PubMedCrossRefGoogle Scholar
  2. 2.
    Mogensen CE: Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 310: 356–360, 1984.PubMedCrossRefGoogle Scholar
  3. 3.
    Viberti GC, Hill RD, Jarrett, RJ, et al.: Microalbuminuria as a prediction of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1: 1430–1432, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Friedman EA: Diabetic renal disease. In: Ellenberg M, Rifkin H (eds) Diabetes mellitus: theory and practice, 3rd edn. New York: Medical Examination Publishing, 1983, pp 759–776.Google Scholar
  5. 5.
    Krolewski AS, Warram JH, Christlieb AR, et al.: The changing natural history of nephropathy in type I diabetes. Am J Med 78: 785–794, 1985.PubMedCrossRefGoogle Scholar
  6. 6.
    Osterby R: Early phases in the development of diabetic glomerulopathy: a quantitative electron microscopic study. Acta Med Scand [Suppl 574] 197: 1–82, 1974.Google Scholar
  7. 7.
    Herman WH, Teutsch SM: Renal disorders associated with diabetes mellitus. In: Friedman EA, L’Esperance FA (eds) Diabetic renal—retinal syndrome, 3. Orlando FL: Grune and Stratton, 1986, pp 9–52.Google Scholar
  8. 8.
    Bjerkelund CJ: Diabetic renal disease: clinical studies of 1,335 diabetics treated in Med. Dept. A of the University Hospital, Oslo 1930–1950. Acta Med Scand 139: 133–145, 1951.PubMedCrossRefGoogle Scholar
  9. 9.
    MacNeal PS, Rogers J: Symposium on diabetes and obesity: complications of diabetes mellitus. Med Clin North Am 39: 1607, 1955.Google Scholar
  10. 10.
    El Mahallawy MN, Sabour MS: Etiologic factors in diabetic nephropathy. JAMA 173: 1783–1788, 1960.CrossRefGoogle Scholar
  11. 11.
    Marble A: The natural history of diabetes. Horm Metab Res [Suppl.] 4: 153–157, 1974.Google Scholar
  12. 12.
    West KM, Erdreich L, Stober JA: A detailed study of risk factors for retinopathy and nephropathy in diabetes. Diabetes 29: 501–508, 1980.PubMedCrossRefGoogle Scholar
  13. 13.
    Andersen AR, Andersen JK, Christiansen JS, et al.: Prognosis for juvenile diabetes with nephropathy and failing renal function. Acta Med Scand 203: 131–134, 1978.PubMedCrossRefGoogle Scholar
  14. 14.
    Waring GO: The sequelae of diabetes mellitus in midwestern American Indians. Diabetes 19: 403–404, 1970.Google Scholar
  15. 15.
    West KM: Diabetes in American Indians and other native populations of the new world. Diabetes 23: 841–855, 1974.PubMedGoogle Scholar
  16. 16.
    Eggers PW, Connerton P, McMullan M: The Medicare experience with end-stage renal disease. Health Care Financing Rev 5: 69–88, 1984.Google Scholar
  17. 17.
    Easterling RE: Racial factors in the incidence and causation of end-stage renal disease. Trans Am Soc Artif Intern Organs 23: 28–33, 1977.PubMedCrossRefGoogle Scholar
  18. 18.
    Health Care Financing Administration, Bureau of Data Management and Strategy: Data from the Program Management and Medical Information Systems, 1979–1984, and census population estimates. Series P-25, no. 965.Google Scholar
  19. 19.
    Rettig BS, Teutsch SM: The incidence of end-stage renal disease in type I and type 11 diabetes mellitus. Diabetic Nephropathy 3: 26–27, 1984.Google Scholar
  20. 20.
    European Dialysis and Transplant Association (EDTA) Annual Report, 1983.Google Scholar
  21. 21.
    Entmacher PS, Root HF, Marks HH: Longevity of diabetic patients in recent years. Diabetes 13: 373–377, 1964.PubMedGoogle Scholar
  22. 22.
    Bell ET: Renal vascular disease in diabetes mellitus. Diabetes 2: 376–389, 1953.PubMedGoogle Scholar
  23. 23.
    Warren S, LeCompte PM, Legg MA: The pathology of diabetes mellitus, 4th edn. Philadelphia: Lea and Febiger, 1966, pp 512–513.Google Scholar
  24. 24.
    Goto Y, Sato SI, Masuda M: Causes of death in 3,151 diabetic autopsy cases. Tohoku J Exp Med 112: 339–353, 1974.PubMedCrossRefGoogle Scholar
  25. 25.
    Balodimos MC: Diabetic nephropathy. In: Marble A, White P, Bradley RF, Krall LP (eds) Joslin’s diabetes mellitus 11th edn. Philadelphia: Lea and Febiger, 1978, pp 526–561.Google Scholar
  26. 26.
    Borch-Johnsen K, Andersen PK, Deckert T: The effect of proteinuria on relative mortality in type I (insulin-dependent) diabetes mellitus. Diabetologia 28: 590–596, 1985.PubMedCrossRefGoogle Scholar
  27. 27.
    National Center for Health Statistics. US Department of Health and Human Services: Multiple cause of death data, Hyattsville, MD 1979.Google Scholar
  28. 28.
    Caird FJ: Survival of diabetics with proteinuria. Diabetes 10: 178–181, 1961.PubMedGoogle Scholar
  29. 29.
    Shapiro FL, Comty CM: Hemodialysis in diabetics: 1981 update. In: Friedman EA, L’Esperance FA (eds) Diabetic renal-retinal syndrome, 2. New York: Grune and Stratton, 1982, pp 65–72.Google Scholar
  30. 30.
    Kass EH: Pyelonephritis and bacteriuria: a major problem in preventive medicine. Ann Intern Med 56: 46–53, 1962.PubMedGoogle Scholar
  31. 31.
    Vejlsgaard R: Studies on urinary infection in diabetics. I. Bacteriuria in patients with diabetes mellitus and in control subjects. Acta Med Scand 179: 173–182, 1966.PubMedCrossRefGoogle Scholar
  32. 32.
    Eknoyan G, Qunibi WY, Grissom RT, et al.: Renal papillary necrosis: an update. Medicine 61: 55–73, 1982.PubMedCrossRefGoogle Scholar
  33. 33.
    D’Elia JA, Gleason RE, Alday M, et al.: Nephrotoxicity from angiographie contrast material. Am J Med 72: 719–725, 1982.CrossRefGoogle Scholar
  34. 34.
    Weinrauch LA, Healy RW, Leland OS, et al.: Coronary angiography and acute renal failure in diabetic azotemic nephropathy. Ann Intern Med 86: 56–59, 1977.PubMedGoogle Scholar
  35. 35.
    Harkonen S, Kjellstrand CM: Exacerbation of diabetic renal failure following intravenous pyelography. Am J Med 63: 939–946, 1977.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1988

Authors and Affiliations

  • Stephen J. Sepe
  • Steven M. Teutsch

There are no affiliations available

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