Microalbuminuria and Diabetic Pregnancy

  • Carl Erik Mogensen
  • J. G. Klebe
Part of the Topics in Renal Medicine book series (TIRM, volume 6)


Renal and vascular damage, including blood pressure elevation, is often involved in complications of diabetic pregnancy. Therefore, sensitive methods for measuring elevated urinary protein excretion, especially of albumin (so-called microalbuminuria) [1–3], might be useful in early prediction of complications in diabetic as well as nondiabetic pregnancy. This is the case in nonpregnant diabetics [3–9], in whom microalbuminuria is a sensitive marker of generalized subclinical vascular disturbance and damage [6] and in whom it predicts overt nephropathy [3–6] as well as proliferative retinopathy [7]. This chapter deals with the pattern of urinary albumin excretion rate in diabetic pregnancy as studied with a sensitive radioimmunoassay for albumin using 24-h urine samples. Patients with overt nephropathy are discussed in chapter 28.


Diabetic Nephropathy Normal Pregnancy Proliferative Diabetic Retinopathy Urinary Albumin Excretion Proliferative Retinopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mogensen CE: Microalbuminuria as a predictor of clinical diabetic nephropathy [Nephrology forum]. Kidney Int 31: 673–689, 1987.PubMedCrossRefGoogle Scholar
  2. 2.
    Viberti GC, Mackintosh D, Bilous RW, Pickup JC, Keen H: Proteinuria in diabetes mellitus: role of spontaneous and experimental variation of glycaemia. Kidney Int 21: 714–720, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Mogensen CE, Christensen CK: Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 311: 89–93, 1984.PubMedCrossRefGoogle Scholar
  4. 4.
    Viberti GC, Hill RD, Jarrett RJ, Argyropoulos A, Mahmud U, Keen H: Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1: 1430–1432, 1982.PubMedCrossRefGoogle Scholar
  5. 5.
    Parving H-H, Oxenboll B, Svendsen PA, Christiansen JS, Andersen AR: Early detection of patients at risk of developing diabetic nephropathy: a longitudinal study of urinary albumin excretion. Acta Endocrinol (Copenh) 100: 550–555, 1982.Google Scholar
  6. 6.
    Mathiesen ER, Oxenbell B, Johansen K, Svendsen PAa, Deckert T: Incipient nephropathy in type 1 (insulin-dependent) diabetes. Diabetologia 26: 406–410, 1984.PubMedCrossRefGoogle Scholar
  7. 7.
    Vigstrup J, Mogensen CE: Proliferative diabetic retinopathy: at risk patients identified by early detection of microalbuminuria. Acta Ophthalmol Scand 63: 530–534, 1985.Google Scholar
  8. 8.
    Feldt-Rasmussen B: Increased transcapillary escape rate of albumin in type 1 (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 29: 282–286, 1986.PubMedCrossRefGoogle Scholar
  9. 9.
    Feldt-Rasmussen B, Mathiesen E, Deckert T: Effect of two years of strict metabolic control on the progression of incipient nephropathy in insulin-dependent diabetes. Lancet 2: 1300 1304, 1986.Google Scholar
  10. 10.
    Miles DW, Mogensen CE, Gundersen HJG: Radioimmunoassay for urinary albumin using a single antibody. Scand J Clin Lab Invest 26: 5–11, 1970.PubMedCrossRefGoogle Scholar
  11. 11.
    Mogensen CE: Microalbuminuria and kidney function: notes on methods, interpretation, and classification. In: Clarke WL, Lamer J, Pohl SL (eds) Methods in diabetes research, vol 2: clinical methods. New York: John Wiley and Sons, 1986, p 612.Google Scholar
  12. 12.
    Mogensen CE, Chachati A, Christensen CK, Close CF, Deckert T, Hommel E, Kastrup J, Lefebvre P, Mathiesen ER, Feldt-Rasmussen B, Schmitz A, Viberti GC: Microalbuminuria: an early marker of renal involvement in diabetes. Uremia Invest 9: 85–95, 1985–1986.Google Scholar
  13. 13.
    Pedersen EB, Rasmussen AB, Johannesen P, Lauritsen JG, Kristensen S, Mogensen CE, Selling K, Wohlert M: Urinary excretion of albumin, beta-2-microglobulin and light chains in preeclampsia, essential hypertension in pregnancy and normotensive pregnant and nonpregnant control subjects. Scand J Clin Lab Invest 41: 777–784, 1982.CrossRefGoogle Scholar
  14. 14.
    Lopez-Espinoza I, Dhar H, Humphreys S, Redman CWG: Urinary albumin excretion in pregnancy. Br J Obstet Gynaecol 93: 176–181, 1986.PubMedCrossRefGoogle Scholar
  15. 15.
    Irgens-Moller L, Hemmingsen L, Holm J: Diagnostic value of microalbuminuria in pre-eclampsia. Clin Chim Acta 157: 295–298, 1986.PubMedCrossRefGoogle Scholar
  16. 16.
    Freinkel N, Dooley SL, Metzger BE: Care of the pregnant woman with insulin-dependent diabetes mellitus. N Engl J Med 313: 96–101, 1985.PubMedCrossRefGoogle Scholar
  17. 17.
    Pedersen J: The pregnant diabetic and her newborn, 2nd edn. Copenhagen: Munksgaard, 1977.Google Scholar
  18. 18.
    Redman CWG: The definition of pre-eclampsia. Scand J Clin Lab Invest [Suppl 169] 44: 7–14, 1984.CrossRefGoogle Scholar
  19. 19.
    Gregorini G, Perico N, Remuzzi G: 2. Pathogenesis of preeclampsia. In: Andreucci VE (ed) The kidney in pregnancy. Boston: Martinus Nijhoff, 1986, pp 13–33.CrossRefGoogle Scholar
  20. 20.
    Harmoinen A, Ala-Houhala I, Vuorinen P: Rapid and sensitive immunoassay for albumin determination in urine. Clin Chim Acta 149: 269–274, 1985.PubMedCrossRefGoogle Scholar
  21. 21.
    Klebe JG, Mogensen CE: Microalbuminuria in diabetic pregnancy: a marker of complications, including intrauterine death. (Submitted for publication, 1987.)Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1988

Authors and Affiliations

  • Carl Erik Mogensen
  • J. G. Klebe

There are no affiliations available

Personalised recommendations