Microalbuminuria and Diabetic Pregnancy
Renal and vascular damage, including blood pressure elevation, is often involved in complications of diabetic pregnancy. Therefore, sensitive methods for measuring elevated urinary protein excretion, especially of albumin (so-called microalbuminuria) [1–3], might be useful in early prediction of complications in diabetic as well as nondiabetic pregnancy. This is the case in nonpregnant diabetics [3–9], in whom microalbuminuria is a sensitive marker of generalized subclinical vascular disturbance and damage  and in whom it predicts overt nephropathy [3–6] as well as proliferative retinopathy . This chapter deals with the pattern of urinary albumin excretion rate in diabetic pregnancy as studied with a sensitive radioimmunoassay for albumin using 24-h urine samples. Patients with overt nephropathy are discussed in chapter 28.
KeywordsDiabetic Nephropathy Normal Pregnancy Proliferative Diabetic Retinopathy Urinary Albumin Excretion Proliferative Retinopathy
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- 5.Parving H-H, Oxenboll B, Svendsen PA, Christiansen JS, Andersen AR: Early detection of patients at risk of developing diabetic nephropathy: a longitudinal study of urinary albumin excretion. Acta Endocrinol (Copenh) 100: 550–555, 1982.Google Scholar
- 7.Vigstrup J, Mogensen CE: Proliferative diabetic retinopathy: at risk patients identified by early detection of microalbuminuria. Acta Ophthalmol Scand 63: 530–534, 1985.Google Scholar
- 9.Feldt-Rasmussen B, Mathiesen E, Deckert T: Effect of two years of strict metabolic control on the progression of incipient nephropathy in insulin-dependent diabetes. Lancet 2: 1300 1304, 1986.Google Scholar
- 11.Mogensen CE: Microalbuminuria and kidney function: notes on methods, interpretation, and classification. In: Clarke WL, Lamer J, Pohl SL (eds) Methods in diabetes research, vol 2: clinical methods. New York: John Wiley and Sons, 1986, p 612.Google Scholar
- 12.Mogensen CE, Chachati A, Christensen CK, Close CF, Deckert T, Hommel E, Kastrup J, Lefebvre P, Mathiesen ER, Feldt-Rasmussen B, Schmitz A, Viberti GC: Microalbuminuria: an early marker of renal involvement in diabetes. Uremia Invest 9: 85–95, 1985–1986.Google Scholar
- 13.Pedersen EB, Rasmussen AB, Johannesen P, Lauritsen JG, Kristensen S, Mogensen CE, Selling K, Wohlert M: Urinary excretion of albumin, beta-2-microglobulin and light chains in preeclampsia, essential hypertension in pregnancy and normotensive pregnant and nonpregnant control subjects. Scand J Clin Lab Invest 41: 777–784, 1982.CrossRefGoogle Scholar
- 17.Pedersen J: The pregnant diabetic and her newborn, 2nd edn. Copenhagen: Munksgaard, 1977.Google Scholar
- 21.Klebe JG, Mogensen CE: Microalbuminuria in diabetic pregnancy: a marker of complications, including intrauterine death. (Submitted for publication, 1987.)Google Scholar