Skip to main content

Nonglycemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake

  • Chapter
The Kidney and Hypertension in Diabetes Mellitus

Part of the book series: Topics in Renal Medicine ((TIRM,volume 6))

Abstract

The evolution of diabetic renal disease is hardly affected by correction of the metabolic disturbance of diabetes [1] and appears to recognize other determinants of progression [2]. Levels of arterial pressure seem important in this respect and have been shown to influence considerably the rate of decline of the glomerular filtration rate (GFR) [3, 4]. This supports the view that hemodynamic factors may have become predominant at this stage of nephropathy [5] and suggests that maneuvers capable of modifying renal and/or systemic vascular dynamics may have independent beneficial effects on the relentless deterioration of renal function in this condition.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Viberti GC, Bilous RW, Mackintosh D, Bending JJ, Keen H: Long-term correction of hyperglycaemia and progression of renal failure in insulin dependent diabetes. Br Med J 286: 598–602, 1983.

    Article  CAS  Google Scholar 

  2. Zatz R, Meyer TW, Rennke HG, Brenner BM: Predominance of haemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy. Proc Natl Acad Sci USA 82: 5963–5967, 1985.

    Article  PubMed  CAS  Google Scholar 

  3. Laffel LMB, Krolewski AS, Raud LI, Warram JH, Christlieb AR, D’Elia JA: The impact of blood pressure on renal function in insulin-dependent diabetes [abstr]. Kidney Int 31: 207, 1987.

    Google Scholar 

  4. Parving HH, Andersen AR, Smidt UM, Svendsen PA: Early aggressive antihypertensive treatment reduces rate of decline in kidney function in diabetic nephropathy. Lancet 2: 1175–1179, 1983.

    Article  Google Scholar 

  5. Hostetter TH, Rennke HG, Brenner BM: The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 72: 375–380, 1982.

    Article  PubMed  CAS  Google Scholar 

  6. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease. N Engl J Med 307: 652–659, 1982.

    Article  PubMed  CAS  Google Scholar 

  7. Hostetter TH, Meyer TW, Rennke HG, Brenner BM: Chronic effects of dietary protein in the rat with intact and reduced renal mass. Kidney Int 30: 509–517, 1986.

    Article  PubMed  CAS  Google Scholar 

  8. Rosman JB, Ter Wee PM, Meiger S, Piers-Becht TPhM, Sluiter WJ, Dohker AbJM: Prospective randomised trial of early dietary protein restriction in chronic renal failure. Lancet 2: 1291–1296, 1984.

    Article  PubMed  CAS  Google Scholar 

  9. Wiseman MJ, Hunt RE, Goodwin A, Gross JL, Keen H, Viberti GC: Dietary composition and renal function in healthy subjects. Nephron 46: 37–42, 1987.

    Article  PubMed  CAS  Google Scholar 

  10. Giovannetti S, Maggiore Q: A low-nitrogen diet with protein of high biological value for severe chronic uremia. Lancet 1: 1000–1003, 1964.

    Article  PubMed  CAS  Google Scholar 

  11. Attman PO, Bucht H, Larsson O, Uddebom G: Protein-reduced diet in diabetic renal failure. Clin Nephrol 19: 217–220, 1983.

    PubMed  CAS  Google Scholar 

  12. Bending JJ, Dodds R, Keen H, Viberti GC: Lowering protein intake and progression of diabetic renal failure. Diabetologia 29: 516A, 1986.

    Google Scholar 

  13. Bending JJ, Dodds R, Li LK, Keen H, Viberti GC: Mechanisms of low dietary protein induced reduction of proteinuria in diabetic nephropathy. Diabetic Med 3: 359A, 1986.

    Google Scholar 

  14. Rosenberg ME, Thomas BL, Swanson JE, Hostetter TH: Effect of protein intake on glomerular function in human renal disease [abstr]. Kidney Int 29: 325, 1986.

    Google Scholar 

  15. Castellino P, Coda B, DeFronzo RA: Effect of amino acid and infusion on renal hemodynamics in humans. Am J Physiol 250: F132 - F140, 1986.

    Google Scholar 

  16. Hostetter TH: Human renal response to a meat meal. Am J Physiol 250: F613–618, 1986.

    PubMed  CAS  Google Scholar 

  17. Bosch JP, Lauer A, Glabman S: Short-term protein loading in assessment of patients with renal disease. Am J Med 77: 873–879, 1984.

    Article  PubMed  CAS  Google Scholar 

  18. Viberti GC, Bognetti E, Wiseman MJ, Dodds R, Gross JL, Keen H: The effect of protein restricted diet on the renal response to a meat meal in man. Am J Physiol (in press), 1987.

    Google Scholar 

  19. Viberti GC, Wiseman MJ: The kidney in diabetes: significance of the early abnormalities. Clin Endocrinol Metab 15: 753–782, 1986.

    Article  PubMed  CAS  Google Scholar 

  20. Wiseman MJ, Bognetti E, Dodds R, Keen H, Viberti GC: Changes in renal function in response to protein restricted diet in type I (insulin-dependent) diabetic subjects. Diabetologia 30: 154–159, 1987.

    Article  PubMed  CAS  Google Scholar 

  21. Wiseman MJ, Saunders AJ, Keen H, Viberti GC: The effect of blood glucose control on increased glomerular filtration rate and kidney size in insulin-dependent diabetes. N Engl J Med 312: 617–621, 1985.

    Article  PubMed  CAS  Google Scholar 

  22. Pulman TN, Alving AS, Dean RJ, Landowne M: The influence of dietary protein on specific renal functions in normal man. J Lab Clin Med 44: 320–332, 1954.

    Google Scholar 

  23. Bergstrom S, Ahlberg M, Alvestrand A: Influence of protein intake on renal haemodynamics and plasma hormone concentration in normal subjects. Acta Med Scand 217: 189–196, 1985.

    Article  PubMed  CAS  Google Scholar 

  24. Viberti GC, Wiseman MJ, Bognetti E, Dodds R, Keen H: Blood glucose and dietary proteins: independent modulators of diabetic glomerular hyperfiltration. Diabetic Nephropathy 5: 31–32, 1986.

    Google Scholar 

  25. Soiling K, Christensen CK, Soiling J, Sandahl Christiansen J, Mogensen CE: Effect on renal haemodynamics, glomerular filtration rate and albumin excretion of high oral protein load. Scand J Clin Lab Invest 46: 351–357, 1986.

    Article  Google Scholar 

  26. El Nahas AM, Paraskevakou H, Zoob S, Evans DJ, Rees AJ: Effect of dietary protein restriction on the development of renal failure after subtotal nephrectomy in rats. Clin Sci 65: 399–406, 1983.

    PubMed  Google Scholar 

  27. Cohen DL, Dodds R, Viberti GC: Effect of protein restricted diet in insulin-dependent diabetics at risk of nephropathy. Br Med J 294: 795–798, 1987.

    Article  CAS  Google Scholar 

  28. Rasch R: Prevention of diabetic glomerulopathy in streptozotocin-diabetic rats by insulin treatment: kidney size and glomerular volume. Diabetologia 16: 125–128, 1979.

    Article  PubMed  CAS  Google Scholar 

  29. Christiansen JS, Gammelgaard J, Tromir B, Svendsen PAa, Parving HH: Kidney function and size in diabetics before and during initial insulin treatment. Kidney Int 21: 683–688, 1982.

    Article  PubMed  CAS  Google Scholar 

  30. Seyer Hansen K: Renal hypertrophy in streptozotocin diabetic rats. Clin Sci 51: 551–555, 1976.

    CAS  Google Scholar 

  31. Elias H, Hemming A: Stereology of the human renal glomerulus. In: Weibel E, Elias H (eds) Quantitative methods in morphology. Berlin: Springer-Verlag, 1967, pp 130–166.

    Google Scholar 

  32. Home PD, Marshall SM: Problems and safety of continuous subcutaneous insulin infusion. Diabetic Med 1: 41–44, 1984.

    Article  PubMed  CAS  Google Scholar 

  33. Macklenburg RS, Benson EA, Benson JW: Acute complications associated with insulin infusion pump therapy. JAMA 252: 3265–3269, 1984.

    Article  Google Scholar 

  34. El Nahas AM, Coles GA: Dietary treatment of chronic renal failure: ten unanswered questions. Lancet 1: 597–600, 1986.

    Article  PubMed  Google Scholar 

  35. Giovannetti S: Answers to ten questions on the dietary treatment of chronic renal failure. Lancet 2: 1140–1142, 1986.

    Article  PubMed  CAS  Google Scholar 

  36. Thomas BJ: Patterns of nutritional intake in diabetics and non diabetics: relationships with vascular disease and its pathogenesis. PhD thesis, University of London, 1982.

    Google Scholar 

  37. Nutrition Sub Committee of the Medical Advisory Committee of the British Diabetic Association: Dietary recommendations for diabetics for the 1980s: The British Diabetic Association, London, 1982.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Viberti, G.C., Dodds, R.A., Bending, J.J., Bognetti, E. (1988). Nonglycemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Topics in Renal Medicine, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1974-1_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1974-1_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1976-5

  • Online ISBN: 978-1-4757-1974-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics