The Concept of Incipient Diabetic Nephropathy and the Longitudinal Course of Microalbuminuria: Effect of Antihypertensive Intervention

  • Cramer K. Christensen
Part of the Topics in Renal Medicine book series (TIRM, volume 6)


Diabetic nephropathy is a well-described entity and increased blood pressure or established hypertension is an early finding in the course of this complication [1, 2], which is characterized by proteinuria and linear decline in glomerular filtration rate (GFR). The presence of high blood pressure superimposed on diabetes represents an additional risk factor in insulin-dependent diabetes mellitus (IDDM) patients [3]. Furthermore, the blood pressure level seems to hasten the rate of progression of renal disease [2], and effective anti-hypertensive therapy can slow the progression rate of overt diabetic nephropathy [2, 4, 5], but unfortunately even optimal antihypertensive treatment, when started in this late stage of nephropathy, cannot stop the decline in GFR but only postpone the development of the uremic stage.


Diabetic Nephropathy Essential Hypertension Antihypertensive Treatment Urinary Albumin Excretion Renal Plasma Flow 
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© Springer Science+Business Media Dordrecht 1988

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  • Cramer K. Christensen

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